Boismare F, Daoust M, Moore N, Saligaut C, Lhuintre J P, Chretien P, Durlach J
Pharmacol Biochem Behav. 1984 Nov;21(5):787-9. doi: 10.1016/s0091-3057(84)80020-9.
The effects of some derivatives of homotaurine (3 APS), the well known GABA agonist, were tested on the voluntary intake of ethanol by rats. Spontaneously ethanol drinking rats (DR) were selected and had a constant voluntary intake of ethanol by rats. Spontaneously ethanol drinking rats (DR) were selected and had a constant voluntary intake of a 12% ethanol solution (VIE) during 14 days (about 5 g/kg body weight daily). Calcium acetylhomotaurine (0.26 and 0.52 mmol/kg daily IP) significantly reduced VIE and this was inhibited by the GABA antagonist bicuculline (2 mg/kg IP). The conditioned aversion test to saccharin was negative. Bicuculline alone did not affect VIE. Other homotaurine (3-APS) derivatives: sodium acetyl homotaurine (Na AOTA), homotaurine (OTA), sodium acetyltaurine (Na A TA) and calcium chloride (CaCl2) did not affect VIE. These data suggest that the gabaergic system could be implicated in VIE. MERAM Lab. patent.
对大鼠自愿摄入乙醇的情况进行了测试，研究了著名的γ-氨基丁酸（GABA）激动剂高牛磺酸（3-APS）的一些衍生物的作用。挑选出自愿饮用乙醇的大鼠（DR），这些大鼠在14天内持续自愿摄入12%的乙醇溶液（VIE）（每天约5克/千克体重）。乙酰高牛磺酸钙（每天腹腔注射0.26和0.52毫摩尔/千克）显著降低了VIE，且这一作用被GABA拮抗剂荷包牡丹碱（腹腔注射2毫克/千克）所抑制。对糖精的条件性厌恶试验呈阴性。单独使用荷包牡丹碱不影响VIE。其他高牛磺酸（3-APS）衍生物：乙酰高牛磺酸钠（Na AOTA）、高牛磺酸（OTA）、乙酰牛磺酸钠（Na A TA）和氯化钙（CaCl2）均不影响VIE。这些数据表明，GABA能系统可能与VIE有关。MERAM实验室专利。
