Gosnell B A, Morley J E, Levine A S
Physiol Behav. 1984 Sep;33(3):349-55. doi: 10.1016/0031-9384(84)90153-7.
A large body of evidence suggests that endogenous opioids are involved in the regulation of feeding. As the striatum and globus pallidus have relatively high concentrations of opioid receptors, these areas are possible sites of action for the stimulatory effects of opiates on feeding. To test these possibilities, male rats were lesioned bilaterally in the globus pallidus or striatum. Nocturnal food intake was then measured after the subcutaneous administration of the opiate antagonist, naloxone (0-10 mg/kg). Spontaneous daytime intake was measured after the subcutaneous administration of the kappa opiate agonist ketocyclazocine (0-10 mg/kg). Neither pallidal nor striatal lesions affected the sensitivity of naloxone in reducing food intake. On the other hand, both lesioned groups were 10-100 times less sensitive to the stimulatory effects of ketocyclazocine. These results suggest that the globus pallidus and striatum may be target areas for the stimulatory effects of exogenous opiates on food intake. Additionally, the relationship of these areas to the dopaminergic nigrostriatal tract suggests that feeding regulation may involve an interaction between dopaminergic and opioid systems.
大量证据表明内源性阿片类物质参与进食调节。由于纹状体和苍白球中阿片受体浓度相对较高，这些区域可能是阿片类药物对进食产生刺激作用的作用位点。为了验证这些可能性，对雄性大鼠双侧苍白球或纹状体进行损伤。皮下注射阿片拮抗剂纳洛酮（0 - 10毫克/千克）后，测量夜间食物摄入量。皮下注射κ阿片激动剂酮环唑新（0 - 10毫克/千克）后，测量白天自发食物摄入量。苍白球和纹状体损伤均未影响纳洛酮减少食物摄入量的敏感性。另一方面，两个损伤组对酮环唑新刺激作用的敏感性均降低了10 - 100倍。这些结果表明，苍白球和纹状体可能是外源性阿片类药物对食物摄入量产生刺激作用的靶区域。此外，这些区域与多巴胺能黑质纹状体通路的关系表明，进食调节可能涉及多巴胺能系统和阿片系统之间的相互作用。
