8,15-二羟基二十碳四烯酸异构体的生物学活性
Biological activities of isomers of 8,15-dihydroxyeicosatetraenoic acid.
作者信息
Evans J, Ford-Hutchinson A W, Fitzsimmons B, Rokach J
出版信息
Prostaglandins. 1984 Sep;28(3):435-8. doi: 10.1016/0090-6980(84)90027-3.
PMID:6096926
Abstract
Chemically synthesized 8(S), 15(S)-dihydroxy-5,11-cis-9, 13-trans-eicosatetraenoic acid and 8(R), 15(S)-dihydroxy-5,11-cis-9,13-trans-eicosatetraenoic acid were inactive, in comparison to leukotriene B4, in a human polymorphonuclear leukocyte chemokinetic assay and a rat polymorphonuclear leukocyte aggregation assay.
摘要
与白三烯B4相比，化学合成的8(S), 15(S)-二羟基-5,11-顺式-9,13-反式-二十碳四烯酸和8(R), 15(S)-二羟基-5,11-顺式-9,13-反式-二十碳四烯酸在人多形核白细胞化学动力学测定和大鼠多形核白细胞聚集测定中无活性。
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