Moridera K, Yoshikawa N, Igarashi T
Tohoku J Exp Med. 1983 Dec;141 Suppl:465-9. doi: 10.1620/tjem.141.suppl_465.
The variation in R-R interval in ECG has been reported to decrease in diabetics with autonomic neuropathy. To investigate the diagnostic value of heart rate monitoring and the prevalence of diabetic autonomic neuropathy, R-R interval variations (CVs) were measured, and the relationships between CV and MCV, FCV, SCV, retinopathy, nephropathy, peripheral neuropathy, and duration of diabetes were investigated. 70 diabetics aged 19 approximately 74 were studied. A total of 100 consecutive R-R intervals on ECG were analyzed by computer. 16 patients (22.8%) of 70 had one or more symptoms of autonomic neuropathy, while the prevalence of diabetic autonomic neuropathy indicated by abnormally low CV was 41.4%. Diabetics with retinopathy, nephropathy or peripheral neuropathy had significantly lower CVs than diabetics without these complications (p less than 0.01). The correlation coefficients for CV and duration of diabetes, and CV and SCV were -0.69 and 0.57 respectively (p less than 0.01). CV (%) of R-R interval was a useful parameter for the determination of diabetic autonomic neuropathy and our results showed that autonomic nerve damage was more prevalent than were symptoms of autonomic neuropathy.
据报道，糖尿病自主神经病变患者心电图中R-R间期的变化会减小。为了研究心率监测的诊断价值以及糖尿病自主神经病变的患病率，我们测量了R-R间期变化（CVs），并研究了CV与运动神经传导速度（MCV）、感觉神经传导速度（FCV）、交感神经皮肤反应（SCV）、视网膜病变、肾病、周围神经病变以及糖尿病病程之间的关系。我们对70名年龄在19岁至74岁之间的糖尿病患者进行了研究。通过计算机分析了心电图上连续100个R-R间期。70名患者中有16名（22.8%）有一项或多项自主神经病变症状，而CV异常降低提示的糖尿病自主神经病变患病率为41.4%。患有视网膜病变、肾病或周围神经病变的糖尿病患者的CV显著低于无这些并发症的糖尿病患者（p<0.01）。CV与糖尿病病程以及CV与SCV的相关系数分别为-0.69和0.57（p<0.01）。R-R间期的CV（%）是确定糖尿病自主神经病变的一个有用参数，我们的结果表明自主神经损伤比自主神经病变症状更为普遍。
