Oka H, Mochio S, Sato K, Sato H, Katayama K, Watanabe S, Nohara T, Hasunuma T, Houi K, Isogai Y
Third Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
J Auton Nerv Syst. 1995 Apr 8;52(2-3):203-11. doi: 10.1016/0165-1838(94)00152-a.
We studied autonomic nervous system function using the principle of maximum entropy (ME) to perform spectral analyses of the R-R interval and systolic blood pressure in 32 diabetic patients and 40 healthy controls. The R-R interval and systolic blood pressure were measured using a continuous, noninvasive monitoring system. The power spectra of both the R-R interval (RR) and systolic blood pressure (SYS) were obtained using ME and the areas of two frequency components were measured: a low- (LFC) and a high-frequency component (HFC). The RR-LFC, RR-HFC and SYS-LFC of diabetic patients were significantly smaller than those of healthy controls. The results of the spectral analyses in diabetic patients correlated with neither disease duration nor nephropathy, while the SYS-LFC showed significant correlations with both retinopathy and the delay in median motor nerve conduction velocity. In the mild autonomic neuropathy group, the RR-LFC and SYS-LFC were not differ from those of healthy controls or patients without autonomic neuropathy. However, the RR-HFC was significantly smaller than that of healthy controls or patients without atonomic neuropathy. In the setting of mild diabetic autonomic neuropathy, it was suggested that cardiac parasympathetic dysfunction preceded both alpha and beta sympathetic dysfunction.
我们运用最大熵（ME）原理对32例糖尿病患者和40例健康对照者的R-R间期和收缩压进行频谱分析，以研究自主神经系统功能。使用连续无创监测系统测量R-R间期和收缩压。利用ME获得R-R间期（RR）和收缩压（SYS）的功率谱，并测量两个频率成分的面积：低频成分（LFC）和高频成分（HFC）。糖尿病患者的RR-LFC、RR-HFC和SYS-LFC显著低于健康对照者。糖尿病患者的频谱分析结果与病程和肾病均无相关性，而SYS-LFC与视网膜病变和运动神经传导速度中位数延迟均显著相关。在轻度自主神经病变组中，RR-LFC和SYS-LFC与健康对照者或无自主神经病变的患者无差异。然而，RR-HFC显著低于健康对照者或无自主神经病变的患者。在轻度糖尿病自主神经病变的情况下，提示心脏副交感神经功能障碍先于α和β交感神经功能障碍。
