Sasaki R, Kobayasi T, Kurokawa T, Shibuya D, Tero-Kubota S
Tohoku J Exp Med. 1984 Oct;144(2):203-10. doi: 10.1620/tjem.144.203.
The spin concentration of ascorbate radical in human serum was examined and the existence of the stable equilibrium between the spin concentration of serum ascorbate radical and concentrations of ascorbic acids in healthy subjects was found. The value of the equilibrium constant was independent of age and sex. The administration of ascorbic acid caused the convergence of these values which were scattered within certain ranges in healthy volunteers. The values of the equilibrium constant increased in many patients with various diseases and returned to normal level with improvement of symptoms. These indicate that the equilibrium constant can be used as a clinical index to reflect metabolic state involving ascorbic acid as the radical scavenger.
检测了人体血清中抗坏血酸自由基的自旋浓度，发现健康受试者血清抗坏血酸自由基的自旋浓度与抗坏血酸浓度之间存在稳定的平衡。平衡常数的值与年龄和性别无关。给予抗坏血酸可使健康志愿者中在一定范围内分散的这些值趋于一致。许多患有各种疾病的患者的平衡常数值升高，且随着症状的改善恢复到正常水平。这些表明平衡常数可用作临床指标，以反映涉及抗坏血酸作为自由基清除剂的代谢状态。
