Airaksinen M M, Sainio E L, Leppäluoto J, Kari I
Acta Endocrinol (Copenh). 1984 Dec;107(4):525-30. doi: 10.1530/acta.0.1070525.
Plasma renin activity and the plasma concentrations of aldosterone, TSH, LH and beta-endorphin were radioimmunologically determined in rats after ip administration of 15 mg/kg of 6-methoxy-tetrahydro-beta-carboline (6-MeO-THBC, pinoline), a compound found to occur normally in mammalian and avian pineal gland. A 2.6-fold increase of plasma aldosterone concentration was found and it was preceded by increase of plasma renin activity. An increase was also found in beta-endorphin/beta-lipotrophin concentration while TSH and LH concentrations did not change significantly. The present results do not prove nor exclude the concept that 6-MeO-THBC is the 'adrenoglomerulotropin'. The effects of 6-MeO-THBC on plasma beta-endorphin/beta-lipotrophin levels may be mediated by the dopaminergic or 5-HT-neurones.
腹腔注射15mg/kg的6-甲氧基-四氢-β-咔啉（6-MeO-THBC，松果林）后，用放射免疫法测定大鼠血浆肾素活性以及醛固酮、促甲状腺激素（TSH）、促黄体生成素（LH）和β-内啡肽的血浆浓度。6-MeO-THBC是一种在哺乳动物和鸟类松果体中正常存在的化合物。结果发现血浆醛固酮浓度增加了2.6倍，且在此之前血浆肾素活性增加。β-内啡肽/β-促脂解素浓度也有所增加，而TSH和LH浓度没有显著变化。目前的结果既没有证明也没有排除6-MeO-THBC是“肾上腺皮质促激素”这一概念。6-MeO-THBC对血浆β-内啡肽/β-促脂解素水平的影响可能是由多巴胺能或5-羟色胺能神经元介导的。
