Leino M, Aho I M, Kari E, Gynther J, Markkanen S
Life Sci. 1984 Nov 12;35(20):1997-2001. doi: 10.1016/0024-3205(84)90555-1.
The effects of melatonin and a related 5-methoxy-indole, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THBC) were investigated in rats on the development of retinal degeneration in presence of high intensity illumination (HII). A morphometric method is used in which the degree of degeneration was evaluated by a computer-coupled graphical analyzer. Instead of measuring individual thicknesses of different retinal layers at various loci we measured large areas of retinal light microscopic sections. Thus the influence of sporadic artefactual and other fluctuations in the thickness of various layers of the retina can be essentially reduced. Continuous light produced significant degeneration of the retina and the degree of degeneration was further increased by both studied compounds and even more by 6-MeO-THBC. The role of melatonin and 6-MeO-THBC in retinal physiology is discussed.
在高强度光照（HII）条件下，研究了褪黑素及一种相关的5-甲氧基吲哚，即6-甲氧基-1,2,3,4-四氢-β-咔啉（6-MeO-THBC）对大鼠视网膜变性发展的影响。采用了一种形态计量学方法，其中通过计算机耦合图形分析仪评估变性程度。我们测量的是视网膜光学显微镜切片的大面积区域，而非在不同位点测量不同视网膜层的个体厚度。因此，可基本减少视网膜各层厚度中偶发的人为因素及其他波动的影响。持续光照会导致视网膜发生显著变性，所研究的两种化合物都会进一步加剧变性程度，而6-MeO-THBC的作用更强。文中讨论了褪黑素和6-MeO-THBC在视网膜生理学中的作用。
