Leino M, Markkanen S, Airaksinen M M, Gynther J, Kari I
Acta Ophthalmol (Copenh). 1984 Jun;62(3):364-72. doi: 10.1111/j.1755-3768.1984.tb08416.x.
Many beta-carbolines have recently been shown to occur in the human body and animals. beta-carbolines may act as neuromodulators although their physiological role is not known. We have studied the autoradiographic retinal distribution of intravitreally injected [3H]6-methoxy-tetrahydro-beta-carboline (6-MeO-THBC) in rats. The synaptic and ganglion cell layers accumulate pronounced radioactivity, as do some intra- and extracellular locations in the inner nuclear layer and the outer segments of the photoreceptors. The pigment epithelium gradually accumulates a very dense band of radioactivity. 6-MeO-THBC (pinoline, 5-methoxytryptoline, 6-methoxy-1,2,3,4-tetrahydronorharmane) has been shown to possess many important biochemical and pharmacological properties. It has been demonstrated to occur as a normal constituent in the retina of some animals. The relationship between 6-MeO-THBC, melatonin and other 5-methoxy-indoles is discussed.
最近发现许多β-咔啉存在于人体和动物体内。β-咔啉可能作为神经调节剂发挥作用，尽管其生理作用尚不清楚。我们研究了大鼠玻璃体内注射[3H]6-甲氧基-四氢-β-咔啉（6-MeO-THBC）后的视网膜放射自显影分布。突触层和神经节细胞层积累了明显的放射性，内核层的一些细胞内和细胞外位置以及光感受器的外段也是如此。色素上皮逐渐积累了一条非常密集的放射性带。6-MeO-THBC（匹诺林、5-甲氧基色胺、6-甲氧基-1,2,3,4-四氢去甲哈尔满）已被证明具有许多重要的生化和药理特性。它已被证明是一些动物视网膜中的正常成分。本文讨论了6-MeO-THBC、褪黑素和其他5-甲氧基吲哚之间的关系。
