阿霉素处理的小鼠中线粒体膜的损伤。
Damages of the mitochondrial membrane in Adriamycin treated mice.
作者信息
Praet M, Pollakis G, Goormaghtigh E, Ruysschaert J M
出版信息
Cancer Lett. 1984 Nov;25(1):89-96. doi: 10.1016/s0304-3835(84)80030-0.
PMID:6097353
Abstract
OF1 Swiss male and female mice received adriamycin (ADM) i.p. in increasing doses. Animals were killed after 2 or 4 days. Hearts were removed and mitochondria were isolated. ADM induced an inactivation of the respiratory enzymes closely related to an increase of the mitochondrial membrane viscosity and of the lipid peroxidation. Two ADM derivatives studied similarly did not produce these effects.
摘要
OF1品系的瑞士雄性和雌性小鼠腹腔注射递增剂量的阿霉素（ADM）。2天或4天后处死动物。取出心脏并分离线粒体。阿霉素诱导呼吸酶失活，这与线粒体膜粘度增加和脂质过氧化密切相关。所研究的两种阿霉素衍生物未产生类似效果。
Zotero 插件