Traub W H
Chemotherapy. 1984;30(6):379-86. doi: 10.1159/000238297.
Addition of phenylbutazone (2 mg/ml) to 55 vol% of fresh defibrinated human blood permitted leukocytic ingestion of Serratia marcescens bacteria, but blocked phagocytic killing activity. The group A (phage tail) bacteriocin bA+ 16 served to kill extraphagocytic test bacteria. Five bacterial DNA gyrase inhibitors (ciprofloxacin, enoxacin, norfloxacin, nalidixic acid and pipemidic acid) revealed intraphagocytic bactericidal activity against ingested S. marcescens bacteria of three test strains; the extent of intraphagocytic activity of these drugs approximated that of rifampin. Following combination with unmodified defibrinated human blood (55 vol%), ciprofloxacin, enoxacin, norfloxacin and pipemidic acid yielded additive effects against 3 assay strains of S. marcescens and Escherichia coli strain ATCC 25922; nalidixic acid was inferior in this regard. These data might guide chemotherapy of parenchymatous urinary tract infections.
在55%体积的新鲜去纤维蛋白人血中加入保泰松（2毫克/毫升），可使白细胞摄取粘质沙雷氏菌，但会阻断吞噬杀伤活性。A组（噬菌体尾部）细菌素bA + 16可杀死吞噬细胞外的测试细菌。五种细菌DNA促旋酶抑制剂（环丙沙星、依诺沙星、诺氟沙星、萘啶酸和吡哌酸）对三种测试菌株摄入的粘质沙雷氏菌显示出吞噬细胞内杀菌活性；这些药物的吞噬细胞内活性程度与利福平相近。与未修饰的去纤维蛋白人血（55%体积）联合使用后，环丙沙星、依诺沙星、诺氟沙星和吡哌酸对三种粘质沙雷氏菌测定菌株和大肠杆菌ATCC 25922菌株产生相加作用；萘啶酸在这方面较差。这些数据可能为实质性尿路感染的化疗提供指导。
