Masuda M, Takayama S
Exp Pathol. 1984;26(3):123-9. doi: 10.1016/s0232-1513(84)80039-0.
2-Amino-6-methyldipyrido[1,2-a:3',3'-d]imidazole (Glu-P-1) and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2), which were isolated from a glutamic acid pyrolysate, were proved to be multipotent carcinogens in rats, inducing tumors of the liver, intestine, ear duct and clitoral gland when administered orally to F344 rats. Intestinal tumors were produced for the first time in a series of experiments with heterocyclic amines. Details of the morphologic features of the intestinal tumors induced in F344 rats by Glu-P-1 and Glu-P-2 are described. There were no marked differences between the tumors induced by Glu-P-1 and Glu-P-2. Grossly, the tumors of the small intestine were recognized as papillary, polypoid or umbilicated masses. The most common tumors in the large intestine showed polypoid growth with a short stalk. Histologically, the intestinal tumors were classified as adenomas, adenocarcinomas, and mucinous carcinomas. Several adenocarcinomas were found adjacent to adenomas. Mucinous carcinomas developed only in the small intestine. Most of these tumors showed endophytic growth with extensive mucus production. Tumor tissue from the small intestine transplanted into the subcutis of the flank grew into tumors within 3 months.
从谷氨酸热解产物中分离出的2-氨基-6-甲基二吡啶并[1,2-a:3',3'-d]咪唑（Glu-P-1）和2-氨基二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-2）被证明是大鼠中的多能致癌物，对F344大鼠口服给药时可诱发肝脏、肠道、耳道和阴蒂腺肿瘤。在一系列杂环胺实验中首次产生了肠道肿瘤。描述了Glu-P-1和Glu-P-2在F344大鼠中诱发的肠道肿瘤的形态学特征细节。Glu-P-1和Glu-P-2诱发的肿瘤之间没有明显差异。大体上，小肠肿瘤表现为乳头状、息肉状或脐状肿块。大肠中最常见的肿瘤呈带短蒂的息肉状生长。组织学上，肠道肿瘤分为腺瘤、腺癌和黏液癌。发现一些腺癌与腺瘤相邻。黏液癌仅在小肠中发生。这些肿瘤大多表现为内生性生长并产生大量黏液。从小肠取出的肿瘤组织移植到侧腹皮下，3个月内长成肿瘤。
