Fujii K, Sakai A, Nomoto K, Nakamura K
Department of Pathology, University of Tsukuba, Ibaraki, Japan.
Cancer Lett. 1988 Jul;41(1):75-80. doi: 10.1016/0304-3835(88)90057-2.
The tumorigenic effects of 2 L-glutamic acid pyrolysates to ICR mice were studied. The newborn animals received subcutaneously either 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) or 2-amino-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2). The mice were observed for 1 year. The tumors of the lung and liver were induced. Statistical analysis revealed that the incidences of the lung tumor in the mice given Glu-P-1 or Glu-P-2 and that of liver tumor in the male mice given Glu-P-2 25 mg/kg body wt were significantly higher than those of controls.
研究了2种L-谷氨酸热解产物对ICR小鼠的致瘤作用。新生动物皮下注射2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1）或2-氨基二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-2）。对小鼠进行了1年的观察。诱导出了肺和肝脏肿瘤。统计分析表明，给予Glu-P-1或Glu-P-2的小鼠的肺肿瘤发生率以及给予25mg/kg体重Glu-P-2的雄性小鼠的肝肿瘤发生率均显著高于对照组。
