Denis J, Grippon P, Legendre C, Tubiana J M, Lévy V G
Gastroenterol Clin Biol. 1984 Dec;8(12):920-4.
The authors report a case of fibrolamellar carcinoma of the liver in a young woman with bilateral lung metastases. This tumour was surgically unremovable. Presently, after a chemotherapy with adriamycin and mitomycin, this patient is in good health, two years after initial diagnosis. Review of the literature shows that fibrolamellar carcinoma of the liver occurs mainly in young patients. This tumor is characterised by large polygonal eosinophilic hepatocytes and an abundant fibrous stroma. It can be confused with focal nodular hyperplasia. Resection of the tumor and the methodical, repeated resections of metastases must be performed when possible. Prognosis of this tumor is better than that of the other variants of hepatocellular carcinoma.
作者报告了一例年轻女性肝脏纤维板层癌伴双侧肺转移的病例。该肿瘤无法通过手术切除。目前,在接受阿霉素和丝裂霉素化疗后,该患者在初次诊断两年后健康状况良好。文献回顾显示,肝脏纤维板层癌主要发生在年轻患者中。该肿瘤的特征是大的多边形嗜酸性肝细胞和丰富的纤维间质。它可能与局灶性结节性增生相混淆。可能的情况下必须进行肿瘤切除以及对转移灶进行有计划的反复切除。该肿瘤的预后优于其他肝细胞癌变体。