Suen K C, Magee J F, Halparin L S, Chan N H, Greene C A
Acta Cytol. 1985 Sep-Oct;29(5):867-72.
The major cytologic features seen in fine needle aspirates from two cases of fibrolamellar hepatocellular carcinoma were: liver-like tumor cells, characterized by plump, polygonal forms with eosinophilic, granular cytoplasm; large oval nuclei with extremely prominent solitary nucleoli; and parallel bands of fibrous tissue and fibrocytes seen within the tumor fragments. Other helpful features included intracytoplasmic hyaline globules and well-delineated pale bodies. Clinically, the tumors occurred in young patients with noncirrhotic livers and ran a more favorable course than do other types of hepatocellular carcinoma.
肝样肿瘤细胞，其特征为细胞丰满、呈多边形，胞质嗜酸性、颗粒状；大的椭圆形细胞核，核仁极其突出且单个存在；肿瘤碎片内可见平行的纤维组织带和成纤维细胞。其他有用的特征包括胞质内透明小球和界限清楚的淡染小体。临床上，这些肿瘤发生于无肝硬化的年轻患者，与其他类型的肝细胞癌相比，病程更为良好。
