γ干扰素在小鼠冠状病毒MHV-JHM感染易感小鼠中的作用
The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM.
作者信息
Smith A L, Barthold S W, de Souza M S, Bottomly K
机构信息
Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
出版信息
Arch Virol. 1991;121(1-4):89-100. doi: 10.1007/BF01316746.
Abstract
Infection of BALB/c mice with mouse hepatitis virus, strain JHM (MHV-JHM), at any of several intervals relative to ovalbumin (OVA) administration resulted in elevated OVA-specific IgG 2 a titers. Since gamma interferon (IFN) has been implicated as an up-regulator of IgG 2 a production, attempts were made to determine whether levels of this cytokine were modified in sera of infected mice. Serum IFN-gamma was not detected, but treatment of MHV-JHM-infected mice with monoclonal anti-IFN-gamma antibody resulted in high mortality with decreased survival times, enhanced virus titers in liver and spleen, and more severe virus-associated pathology, compared to mock-treated, infected mice. Immunotherapy with recombinant IFN-gamma ameliorated disease as reflected by mortality rates and virus titers in target organs.
摘要
在相对于卵清蛋白（OVA）给药的几个不同时间间隔的任何一个时间，用小鼠肝炎病毒JHM株（MHV-JHM）感染BALB/c小鼠，都会导致OVA特异性IgG 2a滴度升高。由于γ干扰素（IFN）被认为是IgG 2a产生的上调因子，因此尝试确定感染小鼠血清中这种细胞因子的水平是否发生改变。未检测到血清IFN-γ，但与模拟处理的感染小鼠相比，用单克隆抗IFN-γ抗体治疗MHV-JHM感染的小鼠导致高死亡率、存活时间缩短、肝脏和脾脏中的病毒滴度升高以及更严重的病毒相关病理学变化。用重组IFN-γ进行免疫治疗改善了疾病，这体现在死亡率和靶器官中的病毒滴度上。
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