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编码酵母泛醇 - 细胞色素c还原酶复合体四个亚基的核基因在单倍体基因组中以单拷贝形式存在，并且其中至少两个位于不同的染色体上。

Nuclear genes coding for four subunits of the yeast ubiquinol-cytochrome c reductase complex are present in single copies in the haploid genome and at least two of these are located on different chromosomes.

作者信息

Van Loon A P, Vijn R J, De Groot R J, Polman J E, Grivell L A

出版信息

Mol Gen Genet. 1984;197(2):219-24. doi: 10.1007/BF00330966.

DOI:10.1007/BF00330966
PMID:6097792
Abstract

Genes coding for the 40 kilodaltons (kDa), 17-kDa, 14-kDa and 11-kDa subunits of the ubiquinol-cytochrome c reductase in yeast are present in single copies in the haploid genome. We have mapped each gene to a unique genomic environment and demonstrate that integration of cloned segments into nuclear DNA by homologous crossing-over with the endogenous gene results in the replacement of the corresponding chromosomal restriction fragment by fragments of predicted sizes. Chromosomal mapping, carried out by the procedure of Falco and Botstein 1983, indicates that the gene for the 17-kDa subunit lies on chromosome VI and that for the 11-kDa subunit on chromosome XII.

摘要

酵母中泛醇 - 细胞色素c还原酶40千道尔顿（kDa）、17 - kDa、14 - kDa和11 - kDa亚基的编码基因在单倍体基因组中以单拷贝形式存在。我们已将每个基因定位到独特的基因组环境，并证明通过与内源基因的同源交叉将克隆片段整合到核DNA中会导致相应的染色体限制性片段被预测大小的片段所取代。通过Falco和Botstein 1983年的方法进行的染色体定位表明，17 - kDa亚基的基因位于第六条染色体上，11 - kDa亚基的基因位于第十二条染色体上。

相似文献

1
Nuclear genes coding for four subunits of the yeast ubiquinol-cytochrome c reductase complex are present in single copies in the haploid genome and at least two of these are located on different chromosomes.编码酵母泛醇 - 细胞色素c还原酶复合体四个亚基的核基因在单倍体基因组中以单拷贝形式存在，并且其中至少两个位于不同的染色体上。
Mol Gen Genet. 1984;197(2):219-24. doi: 10.1007/BF00330966.
2
Isolation and characterization of nuclear genes coding for subunits of the yeast ubiquinol-cytochrome c reductase complex.编码酵母泛醇 - 细胞色素c还原酶复合体亚基的核基因的分离与鉴定。
Gene. 1982 Dec;20(3):323-37. doi: 10.1016/0378-1119(82)90201-3.
3
Isolation, characterization and regulation of expression of the nuclear genes for the core II and Rieske iron-sulphur proteins of the yeast ubiquinol-cytochrome c reductase.酵母泛醇 - 细胞色素c还原酶核心II和 Rieske 铁硫蛋白核基因的分离、特性鉴定及表达调控
Gene. 1983 Dec;26(2-3):261-72. doi: 10.1016/0378-1119(83)90196-8.
4
The biosynthesis of the ubiquinol-cytochrome c reductase complex in yeast. DNA sequence analysis of the nuclear gene coding for the 14-kDa subunit.酵母中泛醇 - 细胞色素c还原酶复合物的生物合成。编码14 kDa亚基的核基因的DNA序列分析。
Eur J Biochem. 1984 Jan 2;138(1):169-77. doi: 10.1111/j.1432-1033.1984.tb07896.x.
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The DNA sequence of the nuclear gene coding for the 17-kd subunit VI of the yeast ubiquinol-cytochrome c reductase: a protein with an extremely high content of acidic amino acids.编码酵母泛醇 - 细胞色素c还原酶17-kd亚基VI的核基因的DNA序列：一种酸性氨基酸含量极高的蛋白质。
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6
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7
Biosynthesis of the ubiquinol-cytochrome c reductase complex in yeast. Discoordinate synthesis of the 11-kd subunit in response to increased gene copy number.酵母中泛醇 - 细胞色素c还原酶复合体的生物合成。11-kd亚基响应基因拷贝数增加的不协调合成。
EMBO J. 1983;2(10):1765-70. doi: 10.1002/j.1460-2075.1983.tb01655.x.
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Localization of mucidin-resistant locus muc3 on mitochondrial DNA with respect to ubiquinol-cytochrome c reductase deficient box loci. Locus muc3 is allelic to box2.线粒体DNA上抗粘菌素基因座muc3相对于泛醇-细胞色素c还原酶缺陷框基因座的定位。基因座muc3与框2等位。
Mol Gen Genet. 1980;179(1):141-6. doi: 10.1007/BF00268456.
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J Biol Chem. 1994 Aug 19;269(33):21284-92.
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The nuclear ABC1 gene is essential for the correct conformation and functioning of the cytochrome bc1 complex and the neighbouring complexes II and IV in the mitochondrial respiratory chain.核ABC1基因对于线粒体呼吸链中细胞色素bc1复合体以及相邻的复合体II和IV的正确构象和功能至关重要。
Eur J Biochem. 1997 May 15;246(1):103-11. doi: 10.1111/j.1432-1033.1997.t01-1-00103.x.

引用本文的文献

1
A yeast mutant lacking mitochondrial manganese-superoxide dismutase is hypersensitive to oxygen.缺乏线粒体锰超氧化物歧化酶的酵母突变体对氧气高度敏感。
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3820-4. doi: 10.1073/pnas.83.11.3820.
2
The pathway of electron transfer in the dimeric QH2: cytochrome c oxidoreductase.二聚体QH2：细胞色素c氧化还原酶中的电子传递途径。
J Bioenerg Biomembr. 1986 Jun;18(3):195-224. doi: 10.1007/BF00743464.
3
Genetic map of Saccharomyces cerevisiae, edition 9.酿酒酵母遗传图谱，第9版。

本文引用的文献

1
DNA insertions which affect the expression of the yeast iso-2-cytochrome c gene.影响酵母同工型 2-细胞色素 c 基因表达的 DNA 插入。
Curr Genet. 1983 Apr;7(2):117-22. doi: 10.1007/BF00365636.
2
Transcriptional and translational expression of a chimeric bacterial-yeast plasmid in yeasts.嵌合细菌-酵母质粒在酵母中的转录和翻译表达。
Gene. 1980 Oct;11(1-2):11-9. doi: 10.1016/0378-1119(80)90082-7.
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A rapid chromosome-mapping method for cloned fragments of yeast DNA.一种用于酵母DNA克隆片段的快速染色体定位方法。
Microbiol Rev. 1985 Sep;49(3):181-213. doi: 10.1128/mr.49.3.181-213.1985.
4
Demarcation of a sequence involved in mediating catabolite repression of the gene for the 11 kDa subunit VIII of ubiquinol-cytochrome c oxidoreductase in Saccharomyces cerevisiae.酿酒酵母中泛醇 - 细胞色素c氧化还原酶11 kDa亚基VIII基因的分解代谢物阻遏介导序列的划分。
Nucleic Acids Res. 1988 Jul 11;16(13):5797-811. doi: 10.1093/nar/16.13.5797.
Genetics. 1983 Dec;105(4):857-72. doi: 10.1093/genetics/105.4.857.
4
Multiple, tandem plasmid integration in Saccharomyces cerevisiae.酿酒酵母中多个串联质粒整合
Mol Cell Biol. 1983 Apr;3(4):747-9. doi: 10.1128/mcb.3.4.747-749.1983.
5
The DNA sequence of the nuclear gene coding for the 17-kd subunit VI of the yeast ubiquinol-cytochrome c reductase: a protein with an extremely high content of acidic amino acids.编码酵母泛醇 - 细胞色素c还原酶17-kd亚基VI的核基因的DNA序列：一种酸性氨基酸含量极高的蛋白质。
EMBO J. 1984 May;3(5):1039-43. doi: 10.1002/j.1460-2075.1984.tb01924.x.
6
Isolation, characterization and regulation of expression of the nuclear genes for the core II and Rieske iron-sulphur proteins of the yeast ubiquinol-cytochrome c reductase.酵母泛醇 - 细胞色素c还原酶核心II和 Rieske 铁硫蛋白核基因的分离、特性鉴定及表达调控
Gene. 1983 Dec;26(2-3):261-72. doi: 10.1016/0378-1119(83)90196-8.
7
The biosynthesis of the ubiquinol-cytochrome c reductase complex in yeast. DNA sequence analysis of the nuclear gene coding for the 14-kDa subunit.酵母中泛醇 - 细胞色素c还原酶复合物的生物合成。编码14 kDa亚基的核基因的DNA序列分析。
Eur J Biochem. 1984 Jan 2;138(1):169-77. doi: 10.1111/j.1432-1033.1984.tb07896.x.
8
Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae.明显受调控的串联上游激活位点介导酿酒酵母CYC1基因的分解代谢物阻遏。
Cell. 1984 Feb;36(2):503-11. doi: 10.1016/0092-8674(84)90243-5.
9
Biosynthesis of the ubiquinol-cytochrome c reductase complex in yeast. Discoordinate synthesis of the 11-kd subunit in response to increased gene copy number.酵母中泛醇 - 细胞色素c还原酶复合体的生物合成。11-kd亚基响应基因拷贝数增加的不协调合成。
EMBO J. 1983;2(10):1765-70. doi: 10.1002/j.1460-2075.1983.tb01655.x.
10
Isolation and characterization of nuclear genes coding for subunits of the yeast ubiquinol-cytochrome c reductase complex.编码酵母泛醇 - 细胞色素c还原酶复合体亚基的核基因的分离与鉴定。
Gene. 1982 Dec;20(3):323-37. doi: 10.1016/0378-1119(82)90201-3.