降钙素对促肾上腺皮质激素分泌的影响。

Effect of calcitonin on ACTH secretion.

作者信息

Rapisarda E, Clementi G, Fiore L, Prato A, Ceravolo A, Raffaele R, Scapagnini U

出版信息

Pharmacol Res Commun. 1984 Dec;16(12):1151-9. doi: 10.1016/s0031-6989(84)80080-6.

Abstract

We have investigated the effects of salmon calcitonin injected intracerebroventricularly on adrenocorticotropic (ACTH) secretion in rats. Salmon calcitonin was able to increase significantly (p less than 0.05) ACTH secretion at the dose of 5 ng/rat and (p less than 0.01) at the doses of 12.5, 25 and 50 ng/rat; the effect (50 ng/rat) was maximal at 30 min and still present after 60 and 120 min. The maximal dose of calcitonin produced a significant (p less than 0.05) increase in serum ACTH concentration also in stressed animals. It is suggested that calcitonin may increase serum ACTH secretion by central norepinephrine and/or 5-hydroxytryptamine pathways that regulate corticotropic releasing factor activity.

摘要

我们研究了脑室内注射鲑鱼降钙素对大鼠促肾上腺皮质激素（ACTH）分泌的影响。鲑鱼降钙素在剂量为5 ng/大鼠时能够显著增加（p<0.05）ACTH分泌，在剂量为12.5、25和50 ng/大鼠时显著增加（p<0.01）；50 ng/大鼠剂量的效应在30分钟时最大，60分钟和120分钟后仍存在。降钙素的最大剂量在应激动物中也使血清ACTH浓度显著（p<0.05）升高。提示降钙素可能通过调节促肾上腺皮质激素释放因子活性的中枢去甲肾上腺素和/或5-羟色胺途径增加血清ACTH分泌。