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Inhibition of restraint stress by systemic (Asu1,7) eel-calcitonin.

作者信息

Clementi G, Prato A, Rapisarda E, Conforto G, Mangano O, Caruso A, Scapagnini U

出版信息

J Endocrinol Invest. 1985 Dec;8(6):543-6. doi: 10.1007/BF03348558.

DOI:10.1007/BF03348558
PMID:3833898
Abstract

The effects of different doses of (Asu1,7) eel-calcitonin, iv injected, on gastric secretion were studied in conscious rats with pyloric occlusion. Moreover, we evaluated the activity of this analogue on gastric ulcer formation by restraint stress. It was found that 2.5 or 5 Ul/kg (Asu1,7) eel-calcitonin decreased gastric acid secretion and inhibited the development of stress-induced ulcers in rats. In the isolated rat stomach the peptide at the concentrations of 1 nM to 1 microM did not modify acetylcholine, histamine or 5-hydroxytriptamine-induced contractions. These results suggest that this peripheral activity of (Asu1,7) eel-calcitonin does not involve a direct interference with cholinergic, histaminergic or serotonergic pathways at gastric level.

摘要

相似文献

1
Inhibition of restraint stress by systemic (Asu1,7) eel-calcitonin.
J Endocrinol Invest. 1985 Dec;8(6):543-6. doi: 10.1007/BF03348558.
2
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引用本文的文献

1
Inhibition of gastric secretion and stress-induced ulcers by intravenous Asu(1,7)eel-calcitonin independent of vasopressin.
J Endocrinol Invest. 1987 Jun;10(3):225-8. doi: 10.1007/BF03348115.

本文引用的文献

1
Evidence for calcitonin--a new hormone from the parathyroid that lowers blood calcium.降钙素的证据——一种来自甲状旁腺的新激素，可降低血钙水平。
Endocrinology. 1962 May;70:638-49. doi: 10.1210/endo-70-5-638.
2
Intraventricular calcitonin inhibits gastric acid secretion.脑室内降钙素抑制胃酸分泌。
Science. 1981 Nov 6;214(4521):671-3. doi: 10.1126/science.7292006.
3
Immunoreactive calcitonin in the central nervous system of the pigeon.鸽子中枢神经系统中的免疫反应性降钙素
Brain Res. 1981 May 11;212(1):59-66. doi: 10.1016/0006-8993(81)90032-9.
4
Calcitonin--C.N.S. action to control the pattern of intestinal motility in rats.降钙素——中枢神经系统对大鼠肠道运动模式的控制作用。
Peptides. 1983 Jan-Feb;4(1):63-6. doi: 10.1016/0196-9781(83)90167-5.
5
Hypoprolactinemic action of calcitonin and the tuberoinfundibular dopaminergic system.降钙素与结节漏斗多巴胺能系统的泌乳素降低作用
J Neurochem. 1983 Mar;40(3):885-6. doi: 10.1111/j.1471-4159.1983.tb08063.x.
6
Calcitonin receptors in the central nervous system of the rat.
Endocrinology. 1981 May;108(5):1672-7. doi: 10.1210/endo-108-5-1672.
7
Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin release.[Asu1,7]-鳗鱼降钙素对胃生长抑素和胃泌素释放的影响。
Gut. 1980 Feb;21(2):94-7. doi: 10.1136/gut.21.2.94.
8
Effect of calcitonin on ACTH secretion.降钙素对促肾上腺皮质激素分泌的影响。
Pharmacol Res Commun. 1984 Dec;16(12):1151-9. doi: 10.1016/s0031-6989(84)80080-6.
9
Studies on the role of acid in the pathogenesis of experimental stress ulcers.关于酸在实验性应激性溃疡发病机制中作用的研究。
Psychosom Med. 1970 Jan-Feb;32(1):61-5. doi: 10.1097/00006842-197001000-00005.
10
Gastric ulcers induced by acid accumulation and by stress in pylorus-occluded rats.幽门结扎大鼠因胃酸积聚和应激诱导的胃溃疡。
Eur J Pharmacol. 1974 Apr;26(1):15-21. doi: 10.1016/0014-2999(74)90068-5.