Shabrov A V
Ter Arkh. 1984;56(12):60-4.
A total of 192 subjects with borderline hypertension, essential hypertension (labile and stable patterns) and practically normal persons (controls) were examined. The basal plasma concentration of aldosterone, progesterone and cortisol as well as blood renin activity was measured in all the subjects in the orthostatic position. After intravenous injection of ACTH in a dose of 12.5 Units the blood was collected for analysis after 60 and 120 minutes. The basal level of corticosteroids underwent the most distinct alterations in patients with the labile and stable patterns of essential hypertension. The ACTH test pointed to definite changes in corticosteroid secretion in some subjects with borderline arterial hypertension. The test enabled one to identify a clear-cut dissociation in the aldosterone and progesterone reactions in subjects with stable essential hypertension. The ACTH test also made it possible to reveal a distinct functional relationship between the renin-angiotensin system and adrenal cortex, which was considerably impaired in stable essential hypertension.
共对192名患有临界高血压、原发性高血压（不稳定型和稳定型）以及实际正常的人（对照组）进行了检查。在所有受试者处于直立位时，测量其醛固酮、孕酮和皮质醇的基础血浆浓度以及血浆肾素活性。静脉注射12.5单位促肾上腺皮质激素后，在60分钟和120分钟时采集血液进行分析。在不稳定型和稳定型原发性高血压患者中，皮质类固醇的基础水平发生了最明显的变化。促肾上腺皮质激素试验表明，一些临界动脉高血压患者的皮质类固醇分泌有明确变化。该试验能够确定稳定型原发性高血压患者醛固酮和孕酮反应的明显分离。促肾上腺皮质激素试验还使得揭示肾素-血管紧张素系统与肾上腺皮质之间明显的功能关系成为可能，而这种关系在稳定型原发性高血压中受到了相当大的损害。
