Nekrasova A A, Patrusheva I F
Kardiologiia. 1979 Dec;19(12):20-4.
Fifteen healthy persons and 31 patients with essential hypertension whose ages ranged from 18 to 45 were examined. The basal level of three steroid hormones (progesterone, aldosterone, and cortisol) in blood plasma and their level after loading (walking, furosemid and rest, furosemid and walking) were studied by the radioimmune method. It is shown that in comparison with healthy individuals, patients with essential hypertension are marked by a change in the ratio of the pressor (aldosterone, cortisol) to the depressor (progesterone) hormones in blood plasma during loading. In different types of loading, no direct correlation was found, on the whole, between the degree of the reactions of aldosterone and renin in healthy individuals and in patients with essential hypertension.
对15名年龄在18至45岁之间的健康人和31名原发性高血压患者进行了检查。采用放射免疫法研究了血浆中三种类固醇激素（孕酮、醛固酮和皮质醇）的基础水平及其负荷后（步行、速尿加休息、速尿加步行）的水平。结果表明，与健康个体相比，原发性高血压患者在负荷期间血浆中升压激素（醛固酮、皮质醇）与降压激素（孕酮）的比例发生了变化。总体而言，在不同类型的负荷下，健康个体和原发性高血压患者的醛固酮反应程度与肾素之间未发现直接相关性。
