Suvorov Iu I, Nekrasova A A, Fatula M I, Patrusheva I F, Ustinova S E
Kardiologiia. 1981 Jul;21(7):36-41.
A total of 16 normal subjects and 30 patients with IB (labile hypertension) and IIB (stable hypertension) stages of essential hypertension during excessive salt intake as well as 13 normal persons and 43 patients at the labile and stable stages of essential hypertension on usual salt diet were examined. Renin activity, plasma aldosterone and cortisol levels were studied using radioimmunoassay in the basal conditions and 1 and 5 hours later after intravenous administration of 5% saline solution (3,6-3,8 mu mole of sodium (1 kg body mass). It was demonstrated that the prolonged excessive intake of sodium hydrochloride resulted in the alteration of the functional state of the renin-angiotensin-aldosterone system even in the normal persons. The above alterations are characterized by the loss of the adequate response of the renin-angiotensin system and the adrenal cortex to the increased sodium concentration, and extracellular fluid volume in the body, as well as by the separation of the functions of these two humoral systems.
共对16名正常受试者以及30名患有原发性高血压IB期（不稳定型高血压）和IIB期（稳定型高血压）且处于高盐摄入状态的患者，还有13名正常人和43名处于原发性高血压不稳定期和稳定期且采用常规盐饮食的患者进行了检查。在基础状态下以及静脉注射5%盐溶液（每千克体重3.6 - 3.8微摩尔钠）后1小时和5小时，采用放射免疫分析法研究肾素活性、血浆醛固酮和皮质醇水平。结果表明，即使在正常人中，长期过量摄入盐酸钠也会导致肾素 - 血管紧张素 - 醛固酮系统功能状态的改变。上述改变的特征是肾素 - 血管紧张素系统和肾上腺皮质对体内钠浓度升高、细胞外液量增加的充分反应丧失，以及这两个体液系统功能的分离。
