Doury P, Cristau P, Pattin S, Schwartz J, Roue R
Rev Rhum Mal Osteoartic. 1977 Dec;44(12):715-20.
A report is given on 3 cases of arthritis after cerebrospinal meningitis caused by B meningococci, with a relapsing course in 1 case. The observations are compared with the literature and the characteristics of articular manifestations of meningococcal infections are outlined. Three types are distinguished. Type I is characterized by banal arthralgias masked by the symptoms of meningitis. Type II encompasses septic arthritides preceding or concurring with the meningitis and like the latter sensitive to antibiotics. Type III includes postmeningococcal arthritides with sterile articular fluid refractory to antibiotics and showing a spectacular reaction to non-steroid anti-inflammatory drugs. These arthritides constitute a true infective rheumatism, post-meningococcal rheumatism, and should be related to other post-meningococcal manifestations such as pericarditis, myocarditis, cutaneous and ocular changes. All these manifestations are attributed to the production of immune complexes. Postmeningococcal arthritides, whose characteristics are described, may occur after septic meningococcal arthritis or appear as such. The distinction of postmeningococcal rheumatism where only anti-inflammatory treatment is effective might lead to the question whether certain postgonococcal arthritides refractory to antibiotics and responding to anti-inflammatory drugs are not provoked by an immuno-allergic mechanism leading to postgonococcal rheumatism -a nosological entity that has been abandoned possibly too fully and definitively.
报告了3例由B型脑膜炎球菌引起的脑脊膜炎后关节炎病例,其中1例呈复发病程。将这些观察结果与文献进行了比较,并概述了脑膜炎球菌感染的关节表现特征。区分出三种类型。I型的特征是被脑膜炎症状掩盖的普通关节痛。II型包括在脑膜炎之前或与之同时发生的化脓性关节炎,与脑膜炎一样对抗生素敏感。III型包括脑膜炎球菌感染后的关节炎,其关节液无菌,对抗生素难治,但对非甾体抗炎药有显著反应。这些关节炎构成一种真正的感染性风湿病,即脑膜炎球菌感染后风湿病,应与其他脑膜炎球菌感染后的表现如心包炎、心肌炎、皮肤和眼部变化相关联。所有这些表现都归因于免疫复合物的产生。文中描述了其特征的脑膜炎球菌感染后关节炎,可能发生在化脓性脑膜炎球菌关节炎之后,也可能以这种形式出现。区分仅抗炎治疗有效的脑膜炎球菌感染后风湿病,可能会引发这样一个问题,即某些对抗生素难治且对抗炎药有反应的淋球菌感染后关节炎,是否不是由导致淋球菌感染后风湿病的免疫过敏机制引起的——这是一个可能被过度彻底摒弃的病种。