Calil H M, Lesieur P, Gold P W, Brown G M, Zavadil A P, Potter W Z
Psychiatry Res. 1984 Nov;13(3):231-42. doi: 10.1016/0165-1781(84)90038-6.
Plasma prolactin (PRL), growth hormone (GH), luteinizing hormone (LH), and cortisol were repeatedly measured during the morning over a 4-hour period in patients who received single or chronic doses of desipramine (DMI) or zimelidine (ZIM). Preclinical studies had suggested that DMI, an uptake inhibitor specific for norepinephrine, would have different effects than ZIM, a selective serotinin uptake inhibitor. The GH response to DMI was blunted in the depressed patients. Neither DMI nor ZIM produced changes in LH or cortisol. DMI acutely increased plasma PRL, whereas ZIM had an effect only after chronic pretreatment. Chronic DMI but not ZIM increased baseline PRL. The patterns and magnitude of responses raise questions concerning the role of serotonin and norepinephrine in PRL release in man and the applicability of current preclinical models.
在接受单次或长期剂量去甲丙咪嗪（DMI）或齐美利定（ZIM）治疗的患者中，于上午4小时内多次测量血浆催乳素（PRL）、生长激素（GH）、促黄体生成素（LH）和皮质醇。临床前研究表明，去甲丙咪嗪是一种对去甲肾上腺素具有特异性的摄取抑制剂，其作用可能与选择性5-羟色胺摄取抑制剂齐美利定不同。抑郁症患者对去甲丙咪嗪的GH反应减弱。去甲丙咪嗪和齐美利定均未引起LH或皮质醇的变化。去甲丙咪嗪可使血浆PRL急性升高，而齐美利定仅在长期预处理后才有作用。长期使用去甲丙咪嗪而非齐美利定可使基线PRL升高。这些反应的模式和程度引发了关于5-羟色胺和去甲肾上腺素在人类PRL释放中的作用以及当前临床前模型适用性的问题。
