Wilkins J N, Spar J E, Carlson H E
Research Service, West Los Angeles V.A. Medical Center, California 90073.
Psychoneuroendocrinology. 1989;14(3):195-202. doi: 10.1016/0306-4530(89)90017-6.
Serial blood samples were collected from 15 elderly depressed inpatients, ages 62 to 95 years, following random assignment to a 50 mg oral test dose of desmethylimipramine (DMI) or amitriptyline (AMI). Nine female and six male subjects began the 210-min study at 0800h. Serum growth hormone (hGH), cortisol, and prolactin (hPRL) were determined by radioimmunoassay. Baseline hormone concentrations were related to self and observer ratings of anxiety and depression. There was a trend for the hGH, cortisol, and hPRL concentrations to decline during the period of study. This trend for all three hormones reversed in those subjects receiving DMI, beginning approximately 90 min after drug ingestion. The DMI-induced increase of hGH reached statistical significance at the very end of the sampling period. There was an apparent latency in the DMI-induced effect for all three hormones. There was no stimulatory effect of AMI on hGH, cortisol, or hPRL. The female subjects had higher baseline hGH levels than the men. In addition, a significant negative correlation was found between baseline hPRL levels and self ratings of anxiety.
对15名年龄在62岁至95岁之间的老年抑郁症住院患者进行随机分组，分别给予50毫克去甲丙咪嗪（DMI）或阿米替林（AMI）的口服试验剂量，随后采集系列血样。9名女性和6名男性受试者于08:00开始了这项为期210分钟的研究。采用放射免疫分析法测定血清生长激素（hGH）、皮质醇和催乳素（hPRL）。基线激素浓度与焦虑和抑郁的自评及他评相关。在研究期间，hGH、皮质醇和hPRL浓度有下降趋势。在接受DMI的受试者中，这三种激素的这种趋势在服药后约90分钟开始逆转。在采样期结束时，DMI诱导的hGH升高达到统计学显著性。DMI对所有三种激素的诱导作用存在明显的潜伏期。AMI对hGH、皮质醇或hPRL没有刺激作用。女性受试者的基线hGH水平高于男性。此外，还发现基线hPRL水平与焦虑自评之间存在显著负相关。
