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人类肥胖症中血浆免疫反应性β-内啡肽对葡萄糖摄入的反应。

Plasma immunoreactive beta-endorphin response to glucose ingestion in human obesity.

作者信息

Getto C J, Fullerton D T, Carlson I H

出版信息

Appetite. 1984 Dec;5(4):329-35. doi: 10.1016/s0195-6663(84)80005-7.

DOI:10.1016/s0195-6663(84)80005-7
PMID:6099096
Abstract

Following the oral administration of 100 g of glucose, morbidly-obese subjects and non-obese controls demonstrated increased levels of plasma immunoreactive beta-endorphin. There was a slow rise in plasma immunoreactive beta-endorphin in the non-obese controls throughout the 3-h observation period. The obese subjects demonstrated a delayed and significantly greater rise of plasma immunoreactive beta-endorphin, when compared to the controls. These findings may have implications for further research in human obesity.

摘要

口服100克葡萄糖后,病态肥胖受试者和非肥胖对照组的血浆免疫反应性β-内啡肽水平均升高。在整个3小时的观察期内,非肥胖对照组的血浆免疫反应性β-内啡肽呈缓慢上升趋势。与对照组相比,肥胖受试者的血浆免疫反应性β-内啡肽升高出现延迟且显著更高。这些发现可能对人类肥胖的进一步研究具有启示意义。

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1
Plasma immunoreactive beta-endorphin response to glucose ingestion in human obesity.人类肥胖症中血浆免疫反应性β-内啡肽对葡萄糖摄入的反应。
Appetite. 1984 Dec;5(4):329-35. doi: 10.1016/s0195-6663(84)80005-7.
2
Immunoreactive beta-endorphin increases after i.v. glucose in obese human subjects.在肥胖人类受试者中,静脉注射葡萄糖后免疫反应性β-内啡肽增加。
Brain Res Bull. 1986 Sep;17(3):435-7. doi: 10.1016/0361-9230(86)90251-0.
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Plasma immunoreactive beta-endorphin in bulimics.贪食症患者的血浆免疫反应性β-内啡肽
Psychol Med. 1986 Feb;16(1):59-63. doi: 10.1017/s0033291700002531.
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The effects of glucose ingestion and fasting on plasma immunoreactive beta-endorphin, adrenocorticotropic hormone and cortisol in obese subjects.
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Plasma beta-endorphin in response to oral glucose tolerance test in obese patients.
Horm Metab Res. 1987 May;19(5):204-7. doi: 10.1055/s-2007-1011779.
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Persistence of altered metabolic responses to beta-endorphin after normalization of body weight in human obesity.人类肥胖症患者体重恢复正常后,对β-内啡肽的代谢反应改变依然持续存在。
Acta Endocrinol (Copenh). 1991 Feb;124(2):159-65. doi: 10.1530/acta.0.1240159.
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Hyperglycemia and obesity as determinants of glucose, insulin, and glucagon responses to beta-endorphin in human diabetes mellitus.高血糖和肥胖作为人类糖尿病中葡萄糖、胰岛素和胰高血糖素对β-内啡肽反应的决定因素。
J Clin Endocrinol Metab. 1987 Jun;64(6):1122-8. doi: 10.1210/jcem-64-6-1122.
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Physiological elevations of plasma beta-endorphin alter glucose metabolism in obese, but not normal-weight, subjects.血浆β-内啡肽的生理性升高会改变肥胖受试者而非正常体重受试者的葡萄糖代谢。
Metabolism. 1992 Feb;41(2):184-90. doi: 10.1016/0026-0495(92)90150-9.
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Plasma cortisol and beta-endorphin immunoreactivity in human obesity.人类肥胖症中的血浆皮质醇和β-内啡肽免疫反应性
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Beta-endorphin plasma levels and their dependence on gender during an enteral glucose load in lean subjects as well as in obese patients before and after weight reduction.
Int J Obes. 1991 Jun;15(6):421-7.

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