Wessberg P, Hedner J, Hedner T, Persson B, Jonason J
Eur J Pharmacol. 1984 Oct 30;106(1):59-67. doi: 10.1016/0014-2999(84)90678-2.
The central respiratory effects of various adenosine (A) analogues were studied in halothane-anesthetized rats. Intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of the A analogues (2-Cla, L-PIA, CHA and NECA) reduced minute ventilation (VE) due to decreases in respiratory frequency (f) as well as tidal volume (VT). Dose-dependent effects were seen after i.c.v. L-PIA in both normal and vagotomized rats. Analysis of the A-induced changes using the occluded breath technique revealed an increase in expiratory time (TE) as well as a decrease in inspiratory drive. NECA, a relatively specific A2 agonist seemed to be somewhat more potent in eliciting respiratory depression than a relatively specific A1 agonist like L-PIA. Pretreatment with the methylxanthine theophylline completely antagonized the respiratory depression induced by L-PIA. It is concluded that central A receptors are involved in the central regulation of breathing and that A interacts with the respiratory control system mainly by decreasing inspiratory neural drive and prolonging expiratory time.
在氟烷麻醉的大鼠中研究了各种腺苷（A）类似物的中枢呼吸效应。脑室内（i.c.v.）和腹腔内（i.p.）注射A类似物（2-氯腺苷、L-苯基异丙基腺苷、环戊腺苷和烟酰胺乙腺嘌呤二核苷酸）可降低分钟通气量（VE），这是由于呼吸频率（f）和潮气量（VT）降低所致。在正常和迷走神经切断的大鼠中，脑室内注射L-苯基异丙基腺苷后均出现剂量依赖性效应。使用闭气技术分析A诱导的变化发现呼气时间（TE）增加以及吸气驱动力降低。烟酰胺乙腺嘌呤二核苷酸是一种相对特异性的A2激动剂，在引起呼吸抑制方面似乎比相对特异性的A1激动剂如L-苯基异丙基腺苷更有效。用甲基黄嘌呤茶碱预处理可完全拮抗L-苯基异丙基腺苷诱导的呼吸抑制。得出的结论是，中枢A受体参与呼吸的中枢调节，并且A主要通过降低吸气神经驱动力和延长呼气时间与呼吸控制系统相互作用。
