未能证实μ-异受体。

Failure to demonstrate mu-isoreceptors.

作者信息

Rourke J D, Shaw J S

出版信息

Neuropeptides. 1984 Dec;5(1-3):85-8. doi: 10.1016/0143-4179(84)90033-7.

Abstract

Attempts have been made to confirm reports that naloxonazine and Mr2034 are able to selectively antagonise morphine-induced analgesia and respiratory depression respectively. In the present studies these antagonists proved to be equi-effective against both the analgesic and respiratory depressant effects of morphine, suggesting that these two actions are mediated by a common receptor.

摘要

人们已尝试证实有关纳洛酮嗪和Mr2034能够分别选择性拮抗吗啡诱导的镇痛作用和呼吸抑制作用的报道。在本研究中，这些拮抗剂被证明对吗啡的镇痛和呼吸抑制作用具有同等效力，这表明这两种作用是由共同的受体介导的。