促肾上腺皮质激素未能改变未成熟脑内的传递性点燃现象。

Failure of ACTH to alter transfer kindling in the immature brain.

作者信息

Thompson J, Holmes G L

出版信息

Epilepsia. 1987 Jan-Feb;28(1):17-9. doi: 10.1111/j.1528-1157.1987.tb03615.x.

DOI:10.1111/j.1528-1157.1987.tb03615.x

Abstract

For a study of the effects of ACTH on established seizures, 16-day-old rats that had been previously kindled in the amygdala were given a high daily dosage of ACTH gel for 15 days and then underwent transfer kindling in the contralateral amygdala. There were no significant differences in the rate of transfer kindling between the controls and ACTH-treated rats. This study indicates that in the immature animal ACTH does not alter the kindled state.

摘要

为了研究促肾上腺皮质激素（ACTH）对已确立的癫痫发作的影响，对16日龄先前在杏仁核点燃癫痫的大鼠每日给予高剂量ACTH凝胶，持续15天，然后在对侧杏仁核进行转移点燃。对照组和接受ACTH治疗的大鼠在转移点燃率上没有显著差异。该研究表明，在未成熟动物中，ACTH不会改变点燃状态。