Paula-Barbosa M M, Tavares M A, Borges M M, Gray E G
J Neurocytol. 1984 Dec;13(6):841-7. doi: 10.1007/BF01148588.
Past work on the C.N.S. of nutritionally deprived immature rats shows widespread structural and functional alterations that were not found in nutritionally deprived adults. In the present work we studied cerebellar mossy fibre terminals of adult rats, given a 8% casein diet for periods of 6, 12 and 18 months. After 12 months of the diet, mossy fibre terminals presented a large number of spherical or disc-shaped membrane-free inclusions herein referred to as presynaptic inclusions, with diameters up to 1.3 micron and formed by fine-textured subunits, compacted into 3 nm strands. This material is an extension of the cytoplasmic network of the terminal. No special relationship was observed with the active zones; synaptic vesicles found in the proximity or embedded in these inclusions were often of the flat type, whereas those close to the active zones always appeared spherical. These results show that even in adult rats synaptic terminals are areas sensitive to protein deprivation.
过去对营养缺乏的幼年大鼠中枢神经系统的研究表明，其存在广泛的结构和功能改变，而在营养缺乏的成年大鼠中未发现这些改变。在本研究中，我们对成年大鼠的小脑苔藓纤维终末进行了研究，这些成年大鼠食用8%酪蛋白饮食6个月、12个月和18个月。饮食12个月后，苔藓纤维终末出现大量球形或盘形无膜内含物，在此称为突触前内含物，直径可达1.3微米，由质地细密的亚单位组成，压缩成3纳米的细丝。这种物质是终末细胞质网络的延伸。未观察到与活性区有特殊关系；在这些内含物附近或嵌入其中的突触小泡通常是扁平型的，而靠近活性区的突触小泡总是呈球形。这些结果表明，即使在成年大鼠中，突触终末也是对蛋白质缺乏敏感的区域。
