Effect of cholecystokinin octapeptide on ethanol intake in the rat.

Water-deprived rats received 3%, 6% or 9% ethanol solution or water for 30 min daily. Intraperitoneal injection of cholecystokinin octapeptide (CCK-8, 2.0-4.0 micrograms/kg) significantly and specifically inhibited ethanol intake. The findings are consistent with previous reports of specificity of the inhibition of caloric intake by CCK-8. Administration of CCK-8 may influence ethanol intake by modulating a satiety signal that ordinarily controls ethanol intake.