Kulkosky P J, Chavez M R
Alcohol. 1984 Sep-Oct;1(5):409-12. doi: 10.1016/0741-8329(84)90012-0.
Twenty-three hr water deprived rats received access to 5% ethanol solution for 30 min daily. Intraperitoneal injection of sulphated cholecystokinin octapeptide (CCK-8, 2.0-16.0 micrograms/kg) significantly inhibited ethanol consumption, but injection of desulphated CCK-8 did not affect ethanol consumption. These results confirm a previous report that CCK-8 suppresses ethanol intake, and indicate that inhibition of ethanol consumption by CCK-8 depends on sulphation of its tyrosyl residue. This chemical specificity of action of CCK-8 is also characteristic of other known behavioral and physiological effects of peripherally-administered cholecystokinin-like peptides.
对禁食23小时的大鼠，每天给予其30分钟饮用5%乙醇溶液的机会。腹腔注射硫酸化八肽胆囊收缩素（CCK - 8，2.0 - 16.0微克/千克）可显著抑制乙醇摄入，但注射去硫酸化CCK - 8对乙醇摄入无影响。这些结果证实了之前关于CCK - 8抑制乙醇摄入的报道，并表明CCK - 8对乙醇摄入的抑制作用取决于其酪氨酸残基的硫酸化。CCK - 8这种作用的化学特异性也是外周给予的胆囊收缩素样肽的其他已知行为和生理效应的特征。
