Panichi C, Faravelli C
Istituto delle Malattie Nervose e Mentali, Università di Firenze.
Riv Patol Nerv Ment. 1984 Nov-Dec;105(6):249-82.
Although more than twenty-five years of clinical use and several placebo-controlled studies have demonstrated the clinical effectiveness of anti-depressant drugs, the mechanism through which these drugs function and how they relate to the pathological mechanisms that underlie depressive disorders are still not clear. The present article briefly reviews the literature available on the subject. In chronological order, it examines studies on the clinical effectiveness of antidepressants, their effects on biogenic amine metabolism and on known receptor systems. The existence of possible specific receptor systems for tricyclic anti-depressants, their modifications during depressive illness, the effect of treatment with psychotropic drugs and the role which these systems may play in depression are then illustrated.
尽管超过二十五年的临床应用以及多项安慰剂对照研究已经证明了抗抑郁药物的临床有效性，但这些药物发挥作用的机制以及它们与抑郁症潜在病理机制的关系仍不清楚。本文简要回顾了关于该主题的现有文献。按时间顺序，考察了关于抗抑郁药临床有效性的研究、它们对生物胺代谢和已知受体系统的影响。接着阐述了三环类抗抑郁药可能存在的特异性受体系统、它们在抑郁疾病期间的变化、精神药物治疗的效果以及这些系统在抑郁症中可能发挥的作用。
