Oubiña J R, Videla C M, Carballal G
Cátedra de Microbiología, Parasitología e Inmunología, Facultad Medicina, Universidad de Buenos Aires, Argentina.
Rev Argent Microbiol. 1984;16(2):107-10.
Two Cebus sp surviving acute Junin virus infection, one after intramuscular inoculation with pathogenic XJ and the other after intracerebral inoculation with XJ Clone 3, failed to exhibit persistent infection. Although treatment with immunosuppressive drugs was carried out, no Junin virus was detected in blood or organs in spite of blind passages in mice for the former as well as cocultivation with permissive Vero cells for the latter. Viremia was also ruled out by immunofluorescence on BHK/21 cell culture. These findings correlate with the lack of long-lasting virus in blood observed in humans following the acute phase of Argentine Hemorrhagic Fever.
两只食蟹猴属物种在感染胡宁病毒急性期存活下来，一只经肌肉注射致病性XJ病毒，另一只经脑内接种XJ克隆3病毒，均未出现持续性感染。尽管使用了免疫抑制药物进行治疗，但前者在小鼠体内盲目传代，后者与允许性Vero细胞共培养，均未在血液或器官中检测到胡宁病毒。通过对BHK/21细胞培养进行免疫荧光检测也排除了病毒血症。这些发现与阿根廷出血热急性期后人类血液中缺乏持续存在的病毒相关。
