Samoilovich S R, Carballal G, Frigerio M J, Weissenbacher M C
Facultad de Medicina, UNBA.
Rev Argent Microbiol. 1983;15(2):113-8.
To study Junin virus infection among laboratory workers and to compare immunofluorescence and neutralization tests, blood samples were taken from 48 individuals, of which 42 were considered high risk personnel. None of the 16 low risk workers exhibited antibodies. Neutralizing antibodies were detected in 15 high risk laboratory workers. Nine of the latter were already known to carry antibodies from a previous survey in 1978. Titers detected were either at previous levels or slightly higher. Of the remaining 6 out of the 15 positive cases, 3 showed mild clinical and subclinical infection, equivalent to a 12% incidence rate over the 1978-1980 period. An adequate correlation was observed between neutralization and immunofluorescence test: 66.6% for both positive tests and 97.1% for both negative tests. Although the immunofluorescence test ies easier to perform the neutralization test appears to be more reliable clinically. The overall prevalence rate of neutralizing antibodies among non-vaccinated personnel was almost 19%, which warns against the health hazard involved in Junin virus handling.
为研究实验室工作人员中胡宁病毒感染情况并比较免疫荧光试验和中和试验，对48人采集了血样，其中42人被视为高风险人员。16名低风险工作人员均未表现出抗体。在15名高风险实验室工作人员中检测到中和抗体。其中9人在1978年的一次先前调查中就已被知晓携带抗体。检测到的滴度要么处于先前水平，要么略高。在15例阳性病例中其余6例里，3例表现出轻度临床和亚临床感染，相当于1978 - 1980年期间12%的发病率。观察到中和试验与免疫荧光试验之间有良好相关性：双阳性试验为66.6%，双阴性试验为97.1%。虽然免疫荧光试验更容易操作，但中和试验在临床上似乎更可靠。未接种疫苗人员中中和抗体的总体流行率近19%，这警示了处理胡宁病毒所涉及的健康危害。
