Moellering R C, Krogstad D J, Greenblatt D J
Ann Intern Med. 1981 Mar;94(3):343-6. doi: 10.7326/0003-4819-94-3-343.
The relation between vancomycin clearance and renal function was studied in 22 patients with various degrees of renal functional impairment and in four normal volunteers. Clearance of vancomycin and creatinine were highly correlated (r = 0.92) among 17 persons not on dialysis. In five dialysis patients vancomycin clearance averaged 0.086 mL/min . kg of body weight (+/- SEM = 0.025). These relations enabled us to construct a nomogram for vancomycin dosage adjustment (based on a mean steady-state serum vancomycin concentration of 15 micrograms/mL) in patients with various degrees of renal functional impairment.
对22例不同程度肾功能损害患者及4名正常志愿者进行了万古霉素清除率与肾功能关系的研究。在17名未接受透析的患者中，万古霉素清除率与肌酐清除率高度相关（r = 0.92）。5例透析患者的万古霉素清除率平均为0.086 mL/分钟·千克体重（±标准误 = 0.025）。这些关系使我们能够为不同程度肾功能损害患者构建万古霉素剂量调整列线图（基于平均稳态血清万古霉素浓度为15微克/毫升）。
