Li Gen, Walker Mark J, De Oliveira David M P
School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.
Microorganisms. 2022 Dec 21;11(1):24. doi: 10.3390/microorganisms11010024.
, and are both common commensals and major opportunistic human pathogens. In recent decades, these bacteria have acquired broad resistance to several major classes of antibiotics, including commonly employed glycopeptides. Exemplified by resistance to vancomycin, glycopeptide resistance is mediated through intrinsic gene mutations, and/or transferrable resistance gene cassette-carrying mobile genetic elements. Here, this review will discuss the epidemiology of vancomycin-resistant and in healthcare, community, and agricultural settings, explore vancomycin resistance in the context of and non- mediated resistance development and provide insights into alternative therapeutic approaches aimed at treating drug-resistant and infections.
[细菌名称1]和[细菌名称2]既是常见的共生菌，也是主要的人类机会致病菌。近几十年来，这些细菌已对几大类主要抗生素产生广泛耐药性，包括常用的糖肽类抗生素。以对万古霉素的耐药性为例，糖肽类耐药性是通过内在基因突变和/或携带可转移耐药基因盒的移动遗传元件介导的。在此，本综述将讨论耐万古霉素[细菌名称1]和[细菌名称2]在医疗保健、社区和农业环境中的流行病学，在[细菌名称1]和非[细菌名称1]介导的耐药性发展背景下探讨万古霉素耐药性，并深入了解旨在治疗耐药[细菌名称1]和[细菌名称2]感染的替代治疗方法。
