Lowes J A, Hamer J, Williams G, Houang E, Tabaqchali S, Shaw E J, Hill I M, Rees G M
Lancet. 1980 Jan 19;1(8160):133-6. doi: 10.1016/s0140-6736(80)90614-5.
A retrospective survey of patients with infective endocarditis at St. Bartholomew's Hospital in the decade 1966--75 showed a male/female ratio of 1.5/1. The commonest presenting features were malaise, fever, new cardiac symptoms, heart-failure, splenomegaly, and finger clubbing. The commonest problem during treatment was heart-failure. As in the two previous decades, viridans streptococci were the commonest causative organisms. Acute endocarditis was caused by Staphylococcus aureus. 6 patients' lives were saved by heart-valve replacement during medical treatment. Of 3 patients who relapsed, 1 died. The overall mortality at six months was 20%, compared with 40% in the two previous decades. Of the patients with proven subacute infective endocarditis thought to have received adequate antibiotic treatment, only 5 of 49 (10%) died; in a similar group of patients in the previous decade 19% died. Early surgical intervention probably accounts for the improved prognosis.
对1966年至1975年这十年间在圣巴塞洛缪医院患有感染性心内膜炎的患者进行的回顾性调查显示，男女比例为1.5比1。最常见的临床表现为不适、发热、新出现的心脏症状、心力衰竭、脾肿大和杵状指。治疗期间最常见的问题是心力衰竭。与此前的两个十年一样，草绿色链球菌是最常见的致病微生物。急性心内膜炎由金黄色葡萄球菌引起。在药物治疗期间，有6名患者通过心脏瓣膜置换术挽救了生命。在3例复发的患者中，1例死亡。六个月时的总死亡率为20%，而此前两个十年为40%。在被认为接受了充分抗生素治疗的确诊亚急性感染性心内膜炎患者中，49例中只有5例（10%）死亡；在前一个十年的类似患者组中，死亡率为19%。早期手术干预可能是预后改善的原因。
