Bayliss R, Clarke C, Oakley C M, Somerville W, Whitfield A G, Young S E
Br Heart J. 1984 Mar;51(3):339-45. doi: 10.1136/hrt.51.3.339.
Of 582 episodes of infective endocarditis 75 were attributable to organisms normally resident in the bowel and 12 others were associated with alimentary tract operations, investigations, or disease. The mean age of the 87 patients in this particular group was higher (59.7 years) than that of all the patients with infective endocarditis (51.4 years). As far as could be ascertained 41% had no pre-existing cardiac abnormality, and in a little under a half no predisposing event to initiate the illness was apparent. Where the portal of entry of the organism to the blood stream was evident it was slightly more often in the genitourinary than the alimentary tract. Bowel organisms are no less important than those associated with the teeth in causing infective endocarditis. It is suggested that in all those patients with known cardiac abnormalities and possibly in those over the age of 60 with normal hearts antibiotic cover should be considered when they undergo genitourinary or alimentary tract surgery or instrumentation.
在582例感染性心内膜炎病例中，75例归因于肠道正常寄居菌，另有12例与消化道手术、检查或疾病相关。该特定组87例患者的平均年龄（59.7岁）高于所有感染性心内膜炎患者的平均年龄（51.4岁）。据查明，41%的患者既往无心脏异常，且近半数患者无引发该病的诱发事件。若病原体进入血流的入口明显，那么其经泌尿生殖道进入的情况略多于经消化道进入的情况。肠道细菌在引起感染性心内膜炎方面与牙齿相关细菌同样重要。建议所有已知有心脏异常的患者，可能还包括所有60岁以上心脏正常的患者，在接受泌尿生殖道或消化道手术或器械检查时，都应考虑使用抗生素预防。
