Levo Y
Lancet. 1980 Feb 9;1(8163):285-7. doi: 10.1016/s0140-6736(80)90781-3.
Cryoimmunoglobulins seem to differ from non-cryoimmunoglobulins in not having carbohydrate groups, most probably sialic acid residues. It is proposed that cryoimmunoglobulinaemia is a physiological event and that desialylated immunoglobulins are a normal byproduct of the immune system. The rise in serum levels of cryoimmunoglobulins is either a pre-secretory event which follows enhanced stimulation of B lymphocytes or a post-secretory event secondary to the generation of serum neuraminidase-like activity by invading microorganisms or their products. It is also proposed that the liver is the main organ which removes cryoimmunoglobulins from the serum. The removal is mediated by specific hepatocellular receptors for desialylated glycoprotein. Clinical or subclinical liver diseases are therefore commonly associated with significantly increased levels of serum cryoglobulins.
冷免疫球蛋白似乎与非冷免疫球蛋白不同，在于其没有碳水化合物基团，很可能是唾液酸残基。有人提出冷免疫球蛋白血症是一种生理现象，去唾液酸化的免疫球蛋白是免疫系统的正常副产物。血清冷免疫球蛋白水平的升高要么是B淋巴细胞受到增强刺激后的分泌前事件，要么是入侵微生物或其产物产生血清神经氨酸酶样活性继发的分泌后事件。还有人提出肝脏是从血清中清除冷免疫球蛋白的主要器官。这种清除是由肝细胞对去唾液酸化糖蛋白的特异性受体介导的。因此，临床或亚临床肝脏疾病通常与血清冷球蛋白水平显著升高有关。
