Rodbell M
Nature. 1980 Mar 6;284(5751):17-22. doi: 10.1038/284017a0.
Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors.
激素和神经递质的细胞膜受体与GTP调节蛋白形成寡聚复合物，并抑制后者与GTP反应。激素和神经递质通过解除受体施加的抑制性限制来发挥作用，从而使GTP调节蛋白能够与诸如腺苷酸环化酶等酶相互作用并控制其活性。该理论可能普遍适用于涉及表面受体的膜信号转导。
