普萘洛尔和醋丁洛尔的支气管收缩及β-肾上腺素受体阻断活性比较
A comparison of the bronchoconstrictor and beta-adrenoceptor blocking activity of propranolol and acebutolol.
作者信息
MacLagan J, Ney U M
出版信息
Br J Pharmacol. 1980 Feb;68(2):196-8. doi: 10.1111/j.1476-5381.1980.tb10407.x.
Abstract
The bronchoconstrictor and beta-adrenoceptor blocking activity of (+/-)-propranolol, acebutolol and two of its analogues were compared in a group of littermate rats. Whilst the analogues of acebutolol had similar bronchoconstrictor potency to propranolol, acebutolol had considerably less activity. No correlation could be found between the degree of bronchoconstriction produced by the four drugs and their beta-adrenoceptor blocking activity in the airway smooth muscle. Acebutolol and its analogues show a wide properties could be related to the production of bronchospasm.
摘要
在一组同窝出生的大鼠中比较了（±）-普萘洛尔、醋丁洛尔及其两种类似物的支气管收缩和β-肾上腺素能受体阻断活性。虽然醋丁洛尔的类似物与普萘洛尔具有相似的支气管收缩效力，但醋丁洛尔的活性要低得多。在四种药物引起的支气管收缩程度与其在气道平滑肌中的β-肾上腺素能受体阻断活性之间未发现相关性。醋丁洛尔及其类似物表现出广泛的特性，可能与支气管痉挛的产生有关。
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