Burckhardt D, Raeder E A
Am Heart J. 1980 Apr;99(4):443-5. doi: 10.1016/0002-8703(80)90378-6.
The effect of the beta-blocking drug acebutolol on the severity of cardiac arrhythmias and the incidence of exercise-induced arrhythmias was studied in 15 patients with chronic coronary artery disease using ambulatory Holter monitoring and bicycle ergometry. We found a significantly lower grading of arrhythmias both on long-term ECGs and during and after exercise. Furthermore, there was a significant decrease in the incidence of VPBs during and after exercise (18.15 +/- 7.7 on placebo vs. 3.46 +/- 1.7 on acebutolol). It is concluded that acebutolol favorably influences the incidence and severity of ventricular arrhythmias in patients with chronic coronary artery disease.
采用动态心电图监测和自行车测力计，对15例慢性冠状动脉疾病患者研究了β受体阻滞剂醋丁洛尔对心律失常严重程度及运动诱发心律失常发生率的影响。我们发现，无论是在长期心电图监测中，还是在运动期间及运动后，心律失常的分级均显著降低。此外，运动期间及运动后室性早搏的发生率显著降低（安慰剂组为18.15±7.7，醋丁洛尔组为3.46±1.7）。得出的结论是，醋丁洛尔对慢性冠状动脉疾病患者室性心律失常的发生率和严重程度有有利影响。
