• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

肺炎克雷伯菌谷氨酰胺营养缺陷型中氮代谢的调控

Regulation of nitrogen metabolism in glutamine auxotrophs of Klebsiella pneumoniae.

作者信息

Leonardo J M, Goldberg R B

出版信息

J Bacteriol. 1980 Apr;142(1):99-110. doi: 10.1128/jb.142.1.99-110.1980.

DOI:10.1128/jb.142.1.99-110.1980
PMID:6102985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC293910/
Abstract

We examined the regulation of nitrogen metabolism in four classes (glnA, glnB, glnF, and glnG) of Gln- auxotrophs of Klebsiella pneumoniae. These studies indicate that glutamine synthetase does not directly mediate the physiological response to NH4+ in this organism. We present evidence suggesting that the effect of NH4+ on the expression of genes involved in nitrogen metabolism involves the products of the glnF and glnG genes.

摘要

我们研究了肺炎克雷伯菌谷氨酰胺营养缺陷型的四类(glnA、glnB、glnF和glnG)基因对氮代谢的调控。这些研究表明,谷氨酰胺合成酶并不直接介导该生物体对NH4+的生理反应。我们提供的证据表明,NH4+对参与氮代谢的基因表达的影响涉及glnF和glnG基因的产物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a25e/293910/ed1499e6ad45/jbacter00565-0117-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a25e/293910/ed1499e6ad45/jbacter00565-0117-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a25e/293910/ed1499e6ad45/jbacter00565-0117-a.jpg

相似文献

1
Regulation of nitrogen metabolism in glutamine auxotrophs of Klebsiella pneumoniae.肺炎克雷伯菌谷氨酰胺营养缺陷型中氮代谢的调控
J Bacteriol. 1980 Apr;142(1):99-110. doi: 10.1128/jb.142.1.99-110.1980.
2
Glutamine synthetase of Klebsiella aerogenes: genetic and physiological properties of mutants in the adenylylation system.产气克雷伯菌谷氨酰胺合成酶:腺苷酸化系统中突变体的遗传和生理特性
J Bacteriol. 1977 Feb;129(2):993-1000. doi: 10.1128/jb.129.2.993-1000.1977.
3
Regulatory mutations in the Klebsiella aerogenes structural gene for glutamine synthetase.产气克雷伯菌谷氨酰胺合成酶结构基因中的调控突变。
J Bacteriol. 1977 Oct;132(1):100-5. doi: 10.1128/jb.132.1.100-105.1977.
4
The Klebsiella pneumoniae PII protein (glnB gene product) is not absolutely required for nitrogen regulation and is not involved in NifL-mediated nif gene regulation.肺炎克雷伯菌PII蛋白(glnB基因产物)对于氮调节不是绝对必需的,并且不参与NifL介导的固氮基因调节。
Mol Gen Genet. 1989 Jun;217(2-3):474-80. doi: 10.1007/BF02464920.
5
Complementation analysis of glnA-linked mutations which affect nitrogen fixation in Klebsiella pneumoniae.影响肺炎克雷伯菌固氮作用的谷氨酰胺合成酶基因(glnA)连锁突变的互补分析
Mol Gen Genet. 1981;184(2):213-7. doi: 10.1007/BF00272907.
6
Role of glnA-linked genes in regulation of glutamine synthetase and histidase formation in Klebsiella aerogenes.谷氨酰胺合成酶连接基因在产气克雷伯菌中对谷氨酰胺合成酶和组氨酸酶形成的调控作用。
J Bacteriol. 1982 Apr;150(1):221-30. doi: 10.1128/jb.150.1.221-230.1982.
7
Involvement of the product of the glnF gene in the autogenous regulation of glutamine synthetase formation in Klebsiella aerogenes.产气克雷伯菌中glnF基因产物参与谷氨酰胺合成酶形成的自身调节。
J Bacteriol. 1978 Mar;133(3):1329-38. doi: 10.1128/jb.133.3.1329-1338.1978.
8
Glutamine synthetase of Klebsiella aerogenes: properties of glnD mutants lacking uridylyltransferase.产气克雷伯菌的谷氨酰胺合成酶:缺乏尿苷酰转移酶的glnD突变体的特性
J Bacteriol. 1978 May;134(2):562-8. doi: 10.1128/jb.134.2.562-568.1978.
9
A nonsense mutation in the structural gene for glutamine synthetase leading to loss of nitrogen regulation in Klebsiella aerogenes.产气克雷伯菌中谷氨酰胺合成酶结构基因的无义突变导致氮调节丧失。
Mol Gen Genet. 1982;187(3):414-8. doi: 10.1007/BF00332621.
10
Ammonia-excreting mutants of Klebsiella pneumoniae with a pleiotropic defect in nitrogen metabolism.肺炎克雷伯菌中具有氮代谢多效性缺陷的氨排泄突变体。
Arch Microbiol. 1996 Dec;166(6):388-93. doi: 10.1007/BF01682984.

引用本文的文献

1
Type IV pilin regulation: a transcriptional overview.IV型菌毛调控:转录概述。
Crit Rev Microbiol. 2025 Jun 20:1-28. doi: 10.1080/1040841X.2025.2520778.
2
Construction of new yeast vectors and cloning of the nif (nitrogen fixation) gene cluster of Klebsiella pneumoniae in yeast.在酵母中构建新的酵母载体并克隆肺炎克雷伯氏菌的 nif(氮固定)基因簇。
Curr Genet. 1981 Jul;3(3):173-80. doi: 10.1007/BF00429819.
3
NasT-mediated antitermination plays an essential role in the regulation of the assimilatory nitrate reductase operon in Azotobacter vinelandii.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Purification of glutamine synthetase from a variety of bacteria.从多种细菌中纯化谷氨酰胺合成酶。
J Bacteriol. 1980 Apr;142(1):69-78. doi: 10.1128/jb.142.1.69-78.1980.
3
Regulation of Klebsiella pneumoniae hut operons by oxygen.氧气对肺炎克雷伯菌hut操纵子的调控
NasT 介导的反终止在根瘤菌中同化硝酸盐还原酶操纵子的调控中起着至关重要的作用。
Appl Environ Microbiol. 2012 Sep;78(18):6558-67. doi: 10.1128/AEM.01720-12. Epub 2012 Jul 6.
4
Pleiotropic effect of his gene mutations on nitrogen fixation in Klebsiella pneumoniae.其基因突变对肺炎克雷伯氏菌固氮的多效性影响。
EMBO J. 1982;1(2):197-204. doi: 10.1002/j.1460-2075.1982.tb01147.x.
5
Nitrogen control of the nif regulon in Klebsiella pneumoniae: involvement of the ntrA gene and analogies between ntrC and nifA.肺炎克雷伯菌中固氮基因簇的氮调控:ntrA基因的作用以及ntrC与nifA之间的相似性
EMBO J. 1983;2(1):39-44. doi: 10.1002/j.1460-2075.1983.tb01377.x.
6
Expression of the activating enzyme and Fe protein of nitrogenase from Rhodospirillum rubrum.深红红螺菌固氮酶激活酶和铁蛋白的表达
J Bacteriol. 1982 Nov;152(2):786-91. doi: 10.1128/jb.152.2.786-791.1982.
7
Mutations affecting regulation of the Klebsiella pneumoniae nifH (nitrogenase reductase) promotor.影响肺炎克雷伯菌nifH(固氮酶还原酶)启动子调控的突变
J Bacteriol. 1984 Jan;157(1):143-7. doi: 10.1128/jb.157.1.143-147.1984.
8
Constitutive expression of nitrogen fixation (nif) genes of Klebsiella pneumoniae due to a DNA duplication.由于DNA重复导致肺炎克雷伯菌固氮(nif)基因的组成型表达。
EMBO J. 1982;1(12):1551-8. doi: 10.1002/j.1460-2075.1982.tb01354.x.
9
Regulation of exoprotease production by temperature and oxygen in Vibrio alginolyticus.温度和氧气对溶藻弧菌胞外蛋白酶产生的调控
Arch Microbiol. 1981 Dec;130(4):276-80. doi: 10.1007/BF00425940.
10
Tandem promoters determine regulation of the Klebsiella pneumoniae glutamine synthetase (glnA) gene.串联启动子决定肺炎克雷伯菌谷氨酰胺合成酶(glnA)基因的调控。
Nucleic Acids Res. 1984 Oct 25;12(20):7811-30. doi: 10.1093/nar/12.20.7811.
J Bacteriol. 1980 Feb;141(2):745-50. doi: 10.1128/jb.141.2.745-750.1980.
4
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
5
'Glutamine(amide):2-oxoglutarate amino transferase oxido-reductase (NADP); an enzyme involved in the synthesis of glutamate by some bacteria.谷氨酰胺(酰胺):2-氧化戊二酸氨基转移酶氧化还原酶(NADP);一种参与某些细菌合成谷氨酸的酶。
J Gen Microbiol. 1970 Dec;64(2):187-94. doi: 10.1099/00221287-64-2-187.
6
Genetic and metabolic control of histidase and urocanase in Salmonella typhimurium, strain 15-59.鼠伤寒沙门氏菌15 - 59株中组氨酸酶和尿刊酸酶的遗传与代谢调控
J Biol Chem. 1969 Oct 10;244(19):5392-402.
7
Mapping of polypeptide reinitiation sites within the beta-galactosidase structural gene.β-半乳糖苷酶结构基因内多肽重新起始位点的定位
J Mol Biol. 1969 May 14;41(3):341-7. doi: 10.1016/0022-2836(69)90280-0.
8
Mechanism of the enzymatic inactivation of glutamine synthetase from E. coli.大肠杆菌谷氨酰胺合成酶的酶促失活机制。
Biochem Biophys Res Commun. 1967 Sep 7;28(5):740-5. doi: 10.1016/0006-291x(67)90378-6.
9
Direct selection for P1-sensitive mutants of enteric bacteria.对肠道细菌的P1敏感突变体进行直接筛选。
J Bacteriol. 1974 Jun;118(3):810-4. doi: 10.1128/jb.118.3.810-814.1974.
10
lac Repressor-operator interaction. VI. The natural inducer of the lac operon.乳糖阻遏蛋白-操纵基因相互作用。VI. 乳糖操纵子的天然诱导物。
J Mol Biol. 1972 Aug 28;69(3):397-408. doi: 10.1016/0022-2836(72)90253-7.