Leonardo J M, Goldberg R B
J Bacteriol. 1980 Apr;142(1):99-110. doi: 10.1128/jb.142.1.99-110.1980.
We examined the regulation of nitrogen metabolism in four classes (glnA, glnB, glnF, and glnG) of Gln- auxotrophs of Klebsiella pneumoniae. These studies indicate that glutamine synthetase does not directly mediate the physiological response to NH4+ in this organism. We present evidence suggesting that the effect of NH4+ on the expression of genes involved in nitrogen metabolism involves the products of the glnF and glnG genes.
我们研究了肺炎克雷伯菌谷氨酰胺营养缺陷型的四类(glnA、glnB、glnF和glnG)基因对氮代谢的调控。这些研究表明,谷氨酰胺合成酶并不直接介导该生物体对NH4+的生理反应。我们提供的证据表明,NH4+对参与氮代谢的基因表达的影响涉及glnF和glnG基因的产物。