Demol P, Sarles H
Arch Int Pharmacodyn Ther. 1980 Jan;243(1):164-76.
The effects of the alpha-adrenergic blocking agents, phentolamine and phenoxybenzamine were tested on the exocrine pancreatic secretion of conscious rats. Phentolamine (0.156 mg/kg to 1.25 mg/kg) and phenoxybenzamine (1.25 and 2.5 mg/kg) strongly inhibited basal volume and protein secretion. On the other hand, phentolamine had no effect on the cholecystokinin-pancreozymin or urecholine stimulated exocrine pancreatic secretion. The infusion of phentolamine (1.25 mg/kg/hr) greatly impaired the stimulatory effect on protein secretion induced by soybean trypsin inhibitor and oleic acid. These experiments suggest that alpha-adrenergic blocking agents inhibit pancreatic secretion of the conscious rat by impairment of cholecystokinin-pancreozymin release either by a direct inhibitory action or by blocking a still unknown alpha-adrenergic stimulatory reflex present in the duodenal mucosa.
研究了α-肾上腺素能阻断剂酚妥拉明和酚苄明对清醒大鼠胰腺外分泌的影响。酚妥拉明（0.156mg/kg至1.25mg/kg）和酚苄明（1.25mg/kg和2.5mg/kg）强烈抑制基础体积和蛋白质分泌。另一方面，酚妥拉明对胆囊收缩素-促胰酶素或乌拉胆碱刺激的胰腺外分泌没有影响。输注酚妥拉明（1.25mg/kg/小时）极大地削弱了大豆胰蛋白酶抑制剂和油酸对蛋白质分泌的刺激作用。这些实验表明，α-肾上腺素能阻断剂通过直接抑制作用或通过阻断十二指肠粘膜中存在的仍未知的α-肾上腺素能刺激反射来损害胆囊收缩素-促胰酶素的释放，从而抑制清醒大鼠的胰腺分泌。
