Demol P, Laugier R, Dagorn J C, Sarles H
Arch Int Pharmacodyn Ther. 1979 Nov;242(1):139-48.
The effect of neurotensin on rat pancreatic secretion was studied in the conscious animal as well as on pancreatic lobules. In vivo neurotensin induced a dose-related inhibition of both water and protein basal secretion. Protein secretion was much more depressed than fluid secretion. Neurotensin did not modify the pancreatic response to exogenous secretin or cholecystokinin-pancreozymin, or to intraduodenal infusion of HCl. On the other hand neurotensin totally inhibited the increase in volume as well as in protein output to an intraduodenal infusion of oleic acid, but did not change the delayed inhibitory effect on protein output. In vitro, neurotensin did not affect basal and cholecystokinin stimulated pancreatic secretion. These results indicate that: 1) neurotensin could interfere with the release of hormones from the gut (cholecystokinin, and possibly VIP), 2) neurotensin did not mimic the delayed protein inhibitory effect observed after administration of oleic acid.
在清醒动物以及胰腺小叶上研究了神经降压素对大鼠胰腺分泌的影响。在体内，神经降压素可引起与剂量相关的水和蛋白质基础分泌抑制。蛋白质分泌比液体分泌受到的抑制更明显。神经降压素不改变胰腺对外源性促胰液素或缩胆囊素-促胰酶素的反应，也不改变十二指肠内注入盐酸时的反应。另一方面，神经降压素完全抑制了十二指肠内注入油酸时体积以及蛋白质输出量的增加，但不改变对蛋白质输出的延迟抑制作用。在体外，神经降压素不影响基础分泌以及缩胆囊素刺激的胰腺分泌。这些结果表明：1）神经降压素可能干扰肠道激素（缩胆囊素，可能还有血管活性肠肽）的释放；2）神经降压素不能模拟油酸给药后观察到的延迟蛋白质抑制作用。
