柳氮磺吡啶（SASP）对多形核（PMN）中性粒细胞中性蛋白酶的抑制作用。
Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP).
作者信息
Klessen C
出版信息
Histochemistry. 1980;66(1):43-7. doi: 10.1007/BF00493244.
PMID:6104653
Abstract
Cytochemical methods were used to demonstrate the inhibitory effect of salicylazosulfapyridine (SASP) on the activity of neutral proteases produced by neutrophilic granulocytes (PMN proteases). The SASP metabolites (5-aminosalicylic acid and sulfapyridine), produced by splitting of SASP by bacteria in the colon, did not inhibit the activity of PMN proteases. Paradoxically, sulfapyridine intensified PMN protease activity. A similar effect however could not be demonstrated for 5-aminosalicylic acid.
摘要
采用细胞化学方法来证实柳氮磺胺吡啶（SASP）对嗜中性粒细胞产生的中性蛋白酶（PMN蛋白酶）活性的抑制作用。由结肠内细菌分解SASP产生的SASP代谢产物（5-氨基水杨酸和磺胺吡啶）并不抑制PMN蛋白酶的活性。矛盾的是，磺胺吡啶增强了PMN蛋白酶的活性。然而，5-氨基水杨酸并未表现出类似的作用。
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