Posadas C, Sánchez Torres G, Morales M, Rangel J, Cuéllar A, Serrano P A
Arch Inst Cardiol Mex. 1977 Nov-Dec;47(6):663-72.
Brunner, Laragh et al. have suggested that essential hypertensives with low plasma renin activity (PRA) are at lower risk of myocardial infarction or cerebrovascular accidents than those with high or normal PRA levels. In this paper we report on 63 patients with essential hypertension in whom the relation between PRA and the ocurrence of cardiovascular events was studied. The patients were categorized in high (11%), normal (70%) or low (19%) PRA subgroups, according to their 24-hour sodium excretion. Coronary angiogram was performed in 24 subjects. The three subgroups showed no significant differences in diastolic blood pressure, serum cholesterol levels, smoking habits or obesity. The incidence of cardiovascular complications was similar in patients with high or low PRA levels (28.5% and 33.3% respectively). In those hypertensives in whom coronary angiogram was done, coronary lesions were observed in 80% of the low renin subjects and in 37.5% of those patients with normal PRA. Therefore, no relation between PRA levels and vascular complications was observed in this series of patients. It is conclude that patients with essential hypertension must be treated as soon and effectively as possible regardless of their PRA value.
布伦纳、拉腊格等人指出，血浆肾素活性（PRA）低的原发性高血压患者发生心肌梗死或脑血管意外的风险低于PRA水平高或正常的患者。在本文中，我们报告了63例原发性高血压患者，研究了PRA与心血管事件发生之间的关系。根据患者24小时钠排泄量，将其分为高PRA亚组（11%）、正常PRA亚组（70%）或低PRA亚组（19%）。对24名受试者进行了冠状动脉造影。三个亚组在舒张压、血清胆固醇水平、吸烟习惯或肥胖方面无显著差异。PRA水平高或低的患者心血管并发症发生率相似（分别为28.5%和33.3%）。在进行冠状动脉造影的高血压患者中，低肾素受试者中有80%观察到冠状动脉病变，PRA正常的患者中有37.5%观察到冠状动脉病变。因此，在这组患者中未观察到PRA水平与血管并发症之间的关系。得出的结论是，原发性高血压患者无论其PRA值如何，都必须尽早且有效地进行治疗。
