Theoretical and clinical aspects of the Tourette syndrome (chronic multiple tic).

In three schizophrenic patients long-term neuroleptic treatment induced Tourette-like symptoms. There seems to be a partial overlap in the pathogenesis of Tourette syndrome and tardive dyskinesia. In five Tourette patients treatment with pimozide was very effective inducing only few side-effects. Long-term neuroleptic treatment may, however, aggravate the symptoms in the long run. A combination treatment with tetrabenazine and pimozide is suggested.