• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The effects of the optical isomers of propranolol on functional refractory period in rat isolated myocardium.

作者信息

Tomlinson D R, Haworth S C, Harmsworth N J, Ross A M

出版信息

J Pharm Pharmacol. 1980 Oct;32(10):693-6. doi: 10.1111/j.2042-7158.1980.tb13040.x.

DOI:10.1111/j.2042-7158.1980.tb13040.x
PMID:6107342
Abstract

The two optical isomers of propranolol caused a concentration-dependent increase in functional refractory period of the rat isolated left atrium. In this property the isomers were equipotent. Naradrenaline (1 X 10-(7) M) decreased the functional refractory period. This effect was completely reversed by (-)-propranolol. The (+)-isomer was much less potent than (-)-propranolol in antagonizing the effects of noradrenaline on functional refractory period.

摘要

相似文献

1
The effects of the optical isomers of propranolol on functional refractory period in rat isolated myocardium.
J Pharm Pharmacol. 1980 Oct;32(10):693-6. doi: 10.1111/j.2042-7158.1980.tb13040.x.
2
Effects of alpha- and beta-adrenoceptor blockade on the neurally evoked overflow of endogenous noradrenaline from the rat isolated heart.α-和β-肾上腺素能受体阻断对大鼠离体心脏神经诱发内源性去甲肾上腺素释放的影响。
Br J Pharmacol. 1984 Mar;81(3):475-8. doi: 10.1111/j.1476-5381.1984.tb10100.x.
3
The effect of certain -adrenoceptor antagonists on overdrive suppression.某些β-肾上腺素能受体拮抗剂对超速抑制的作用。
Br J Pharmacol. 1972 Nov;46(3):363-74. doi: 10.1111/j.1476-5381.1972.tb08133.x.
4
Comparative effects of (+)- and (-)-isomers of propranolol and INPEA on (+)-tubocurarine- and succinylcholine-induced neuromuscular blockade.普萘洛尔和去甲丙咪嗪的（+）-和（-）-异构体对（+）-筒箭毒碱和琥珀酰胆碱诱导的神经肌肉阻滞的比较效应。
Eur J Pharmacol. 1975 Sep-Oct;33(2):325-35. doi: 10.1016/0014-2999(75)90177-6.
5
The effects of (+)- and (-)-propranolol on 3H-transmitter efflux in guinea-pig atria and the presynaptic beta-adrenoceptor hypothesis.（+）-和（-）-普萘洛尔对豚鼠心房3H递质外流的影响及突触前β-肾上腺素能受体假说
Br J Pharmacol. 1980 Nov;70(3):491-8. doi: 10.1111/j.1476-5381.1980.tb08728.x.
6
Cardiac responses to VIP and VIP-ergic-cholinergic interaction in isolated dog heart preparations.离体犬心脏标本中血管活性肠肽及血管活性肠肽能-胆碱能相互作用的心脏反应
Eur J Pharmacol. 1990 Oct 2;187(1):9-17. doi: 10.1016/0014-2999(90)90335-4.
7
Effects of the (+/-)-, (+)- and (-)-forms of propranolol, timolol and metoprolol on noradrenergic transmission in the rat isolated right ventricle.普萘洛尔、噻吗洛尔和美托洛尔的（±）-、（+）-和（-）-异构体对大鼠离体右心室去甲肾上腺素能传递的影响。
Arch Int Pharmacodyn Ther. 1984 Jul;270(1):61-78.
8
Possible role of a beta-adrenoceptor in the regulation of noradrenaline release by nerve stimulation through a positive feed-back mechanism.β-肾上腺素能受体通过正反馈机制在神经刺激调节去甲肾上腺素释放中可能发挥的作用。
Br J Pharmacol. 1975 Jan;53(1):43-50. doi: 10.1111/j.1476-5381.1975.tb07328.x.
9
[Effect of adaptation to physical loading on the adrenoreactivity of the isolated rat atrium].
Biull Eksp Biol Med. 1987 Jul;104(7):23-6.
10
Inhibition by propranolol of the contractile response of the rat diaphragm to tetanic field stimulation in vitro.普萘洛尔对大鼠膈肌体外强直场刺激收缩反应的抑制作用。
Br J Pharmacol. 1983 Dec;80(4):613-8. doi: 10.1111/j.1476-5381.1983.tb10050.x.

引用本文的文献

1
Studies on the stereoisomers of beta-adrenoceptor antagonists in conscious A-V blocked dogs.清醒状态下房室传导阻滞犬体内β-肾上腺素能受体拮抗剂立体异构体的研究。
Br J Pharmacol. 1986 Sep;89(1):119-27. doi: 10.1111/j.1476-5381.1986.tb11127.x.